CALCIUM HOMEOSTASIS IN CHRONIC STREPTOZOTOCIN-INDUCED DIABETES-MELLITUS IN THE RAT
CALCIUM HOMEOSTASIS IN CHRONIC STREPTOZOTOCIN-INDUCED DIABETES-MELLITUS IN THE RAT
复制标题
DOI：
10.1152/ajpendo.1982.242.6.e451
复制
发表时间：
1982-01-01
影响因子：
--
通讯作者：
AVIOLI, LV
中科院分区：
文献类型：
--
作者：
HOUGH, S;RUSSELL, JE;AVIOLI, LV
钙稳态研究自由喂养的控制，链脲佐菌素糖尿病，长期和短期胰岛素治疗的糖尿病大鼠7周后诱导糖尿病。与短期（5-12天）糖尿病大鼠模型相反，在慢性胰岛素缺乏动物中，钙的肠吸收显著增强。此外，传统的平衡研究表明，这些动物处于正钙平衡，尽管严重的高钙尿症。尽管循环中1，25-二羟维生素D和皮质酮过多水平较低，但长期糖尿病大鼠的肠道钙吸收过度，并伴有高钙血症和血浆甲状旁腺激素（PTH）和尿cAMP的抑制。长期胰岛素替代完全正常化的钙的肠吸收过度，纠正血浆钙，并显着增加循环PTH和尿cAMP排泄。胰岛素治疗也纠正了在未治疗的糖尿病动物中观察到的血浆1，25-二羟维生素D的降低。短期胰岛素治疗似乎只能部分纠正肠道钙吸收过度。累积的结果揭示了长期糖尿病大鼠和短期糖尿病大鼠之间钙稳态和激素反应的决定性差异。
Ca homeostasis was studied in freely fed control, streptozotocin diabetic, long-term and short-term insulin-treated diabetic rats 7 wk after the induction of diabetes. In contrast to the short-term (5-12 day) diabetic rat model, intestinal absorption of Ca was markedly enhanced in chronically insulin-deficient animals. Moreover, conventional balance studies showed that these animals were in positive Ca balance despite severe hypercalciuria. Intestinal hyperabsorption of Ca in long-standing diabetic rats occurred despite low levels of circulating 1,25-dihydroxyvitamin D and hypercorticosteronism and was attended by hypercalcemia and suppression of both plasma parathyroid hormone (PTH) and urinary cAMP. Long-term insulin replacement completely normalized the intestinal hyperabsorption of Ca, corrected the plasma Ca, and significantly increased circulating PTH and urinary cAMP excretion. Insulin therapy also corrected the decreased plasma 1,25-dihydroxyvitamin D observed in untreated diabetic animals. Intestinal hyperabsorption of Ca appeared to be only partially corrected by short-term insulin therapy. The accumulated results reveal decided differences in Ca homeostasis and hormonal response between the rats with long-standing diabetes and those with diabetes of short duration.