Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota.
Unconventional immune cells in the gut mucosal barrier: regulation by symbiotic microbiota.
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DOI：
10.1038/s12276-023-01088-9
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发表时间：
2023-09
影响因子：
12.8
通讯作者：
Oh, Sungwhan F.
中科院分区：
文献类型：
--
作者：
Yoo, Ji-Sun;Oh, Sungwhan F.
哺乳动物肠道是微生物种类最密集的定植器官，其在整个生命过程中与宿主不断接触。微生物已经开发出多方面的细胞和分子机制来区分和应对良性和致病性细菌。除了相对较好表征的先天性和适应性免疫细胞外，越来越多的证据显示肠道粘膜免疫中还有其他重要的参与者。其中，非常规免疫细胞，包括先天性淋巴细胞（ILC）和非常规T细胞，对于维持体内平衡至关重要。这些细胞迅速响应细菌信号，并在粘膜屏障中连接先天免疫和适应性免疫。在这里，我们专注于这些免疫细胞在生理和病理条件下的类型和作用，作为宿主免疫系统在健康和疾病中与肠道微生物群沟通的重要机制。这项研究强调了微生物群在调节肠道中ILC亚群和非常规T细胞的维持和功能方面的重要作用。微生物定植影响细胞因子的产生，影响ILC在屏障维持和抵抗病原体的保护中的功能。此外，微生物群衍生的抗原形成MAIT和iNKT细胞群，其活性受到微生物群影响的代谢物和局部细胞因子的组合的精细调节。了解这些相互作用可能会导致改善肠道健康和有效治疗免疫介导疾病的创新策略。
The mammalian gut is the most densely colonized organ by microbial species, which are in constant contact with the host throughout life. Hosts have developed multifaceted cellular and molecular mechanisms to distinguish and respond to benign and pathogenic bacteria. In addition to relatively well-characterized innate and adaptive immune cells, a growing body of evidence shows additional important players in gut mucosal immunity. Among them, unconventional immune cells, including innate lymphoid cells (ILCs) and unconventional T cells, are essential for maintaining homeostasis. These cells rapidly respond to bacterial signals and bridge the innate immunity and adaptive immunity in the mucosal barrier. Here, we focus on the types and roles of these immune cells in physiological and pathological conditions as prominent mechanisms by which the host immune system communicates with the gut microbiota in health and diseases. This study highlights the essential role of microbiota in regulating the maintenance and function of ILC subsets and unconventional T cells in the gut. Microbial colonization influences cytokine production, affecting ILC function in barrier maintenance and protection against pathogens. Additionally, microbiota-derived antigens shape MAIT and iNKT cell populations, with their activity finely regulated by a combination of metabolites and local cytokines influenced by the microbiota. Understanding these interactions could lead to innovative strategies for enhancing gut health and effectively treating immune-mediated diseases.
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影响因子：
64.8
作者：
Cella, Marina;Fuchs, Anja;Vermi, William;Facchetti, Fabio;Otero, Karel;Lennerz, Jochen K. M.;Doherty, Jason M.;Mills, Jason C.;Colonna, Marco
通讯作者：
Colonna, Marco
影响因子：
30.5
作者：
Awad, Wael;Ler, Geraldine J. M.;Rossjohn, Jamie
通讯作者：
Rossjohn, Jamie
DOI：
10.1126/science.aax6624
发表时间：
2019-10-25
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Constantinides MG;Link VM;Tamoutounour S;Wong AC;Perez-Chaparro PJ;Han SJ;Chen YE;Li K;Farhat S;Weckel A;Krishnamurthy SR;Vujkovic-Cvijin I;Linehan JL;Bouladoux N;Merrill ED;Roy S;Cua DJ;Adams EJ;Bhandoola A;Scharschmidt TC;Aubé J;Fischbach MA;Belkaid Y
通讯作者：
Belkaid Y
影响因子：
8
作者：
Chan, I. H.;Jain, R.;LaFace, D.
通讯作者：
LaFace, D.
影响因子：
32.4
作者：
Ganal, Stephanie C.;Sanos, Stephanie L.;Diefenbach, Andreas
通讯作者：
Diefenbach, Andreas