Interleukin-6 (IL-6)-572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans
Interleukin-6 (IL-6)-572C→G promoter polymorphism is associated with type 2 diabetes risk in Koreans
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DOI：
10.1111/j.1365-2265.2008.03315.x
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发表时间：
2009-02-01
影响因子：
3.2
通讯作者：
Lee, Jong Ho
中科院分区：
文献类型：
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作者：
Koh, Soo Jeong;Jang, Yangsoo;Lee, Jong Ho
炎症标志物水平升高，如白细胞介素-6（IL-6），与2型糖尿病（T2 DM）相关。我们研究了韩国人IL-6基因多态性与2型糖尿病及IL-6循环水平的关系，共纳入1477名糖耐量正常者和476名2型糖尿病患者，检测了IL-6启动子区-174G -> C、-572C -> G、-597G -> A和-1363G -> T多态性。主要结果指标为2型糖尿病风险的比值比（OR）和血清IL-6和高敏C反应蛋白（hs-CRP）浓度，罕见G等位基因IL-6 - 572 C-> G纯合性与2型糖尿病的高风险相关[OR 1.69（95%CI 1.11-2.58），P = 0.015]。对照组血清IL-6浓度与IL-6 - 572 C-> G基因型相关（G/G：2.33 +/- 0.41：C/G：1.53 +/- 0.09：C/C：1.72 +/- 0.08 ng/l，P = 0.023）。同样在对照组中，罕见G等位基因纯合子受试者的hs-CRP浓度显著高于C/C和C/G携带者（G/G：13.6 +/- 2.9：C/G：9.2 +/- 0.6：C/C：7.8 +/- 0.4 mg/l，P = 0.003）。IL-6 - 174 SNP位点C等位基因非常罕见（< 0.01），-597 G-> A和-1363 G-> T为单态，IL-6 - 572 G/G基因型与血清IL-6和hs-CRP浓度升高及T2 DM风险增加相关。
Increased levels of inflammatory markers, such as interleukin-6 (IL-6), are associated with type 2 diabetes (T2DM). We investigated the association of IL-6 gene polymorphisms with T2DM and circulating levels of IL-6 in Koreans.A total of 1477 subjects with normal glucose tolerance and 476 T2DM patients were included.We examined IL-6 -174G -> C, -572C -> G, -597G -> A and -1363G -> T promoter region polymorphisms. The main outcome measures were the odds ratio (OR) on T2DM risk and serum concentrations of IL-6 and high-sensitivity C-reactive protein (hs-CRP).Homozygosity for the rare G allele IL-6 -572C -> G was associated with a higher risk of T2DM [OR 1.69 (95%CI 1.11-2.58), P = 0.015]. Serum IL-6 concentrations were associated with the IL-6 -572C -> G genotype in control subjects (G/G: 2.33 +/- 0.41: C/G: 1.53 +/- 0.09: C/C: 1.72 +/- 0.08 ng/l, P = 0.023). Also in the control group, subjects homozygous for the rare G allele showed significantly higher concentrations of hs-CRP than C/C and C/G carriers (G/G: 13.6 +/- 2.9: C/G: 9.2 +/- 0.6: C/C: 7.8 +/- 0.4 mg/l, P = 0.003). The C-allele at the IL-6 -174 SNP was very rare (< 0.01) and -597G -> A and -1363G -> T were monomorphic in this population.Our data demonstrate that the IL-6 -572G/G genotype is associated with higher serum IL-6 and hs-CRP concentrations and with increased risk for T2DM.