SERS-active Au@Ag nanorod dimers for ultrasensitive dopamine detection
SERS-active Au@Ag nanorod dimers for ultrasensitive dopamine detection
复制标题
用于超灵敏多巴胺检测的 SERS 活性 Au@Ag 纳米棒二聚体
DOI：
10.1016/j.bios.2015.04.013
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发表时间：
2015-09-15
影响因子：
12.6
通讯作者：
Xu, Chuanlai
中科院分区：
文献类型：
--
作者：
Tang, Lijuan;Li, Si;Xu, Chuanlai
多巴胺(DA)是一种神经递质，在生命科学中起着关键作用。开发了基于适配子的自组装Au@Ag纳米棒二聚体，用于超灵敏的多巴胺检测。在Au-NR二聚体表面添加银壳涂层可显著提高电场强度。结果表明，Au@AgNR二聚体是构建具有显著拉曼增强效应的SERS底物的理想构件。结果表明，利用这种表面增强拉曼散射编码的传感系统，多巴胺的检测下限为0.006 pM，线性范围为0.01-10 pM。我们的工作为诊断和药物发现计划开辟了一条新的途径。(C)2015爱思唯尔B.V.保留所有权利。
Dopamine (DA) is a neurotransmitter which plays a key role in the life science. Self-assembled Au@Ag nanorod dimers based on aptamers were developed for ultrasensitive dopamine detection. The electronic field was significantly enhanced by the addition of silver shell coating on the surface of Au NR dimer. The results displayed that Au@Ag NR dimers were ideal building blocks for constructing the SERS substrates with prominent Raman enhancement effects. It was found that with using this Surface-enhanced Raman scattering (SERS)-encoded this sensing system, a limit of detection of 0.006 pM and a wide linear range of 0.01-10 pM for dopamine detection were obtained. Our work open up a new avenue for the diagnosis and drug-discovery programs. (C) 2015 Elsevier B.V. All rights reserved.