Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis.
Dissociation of neutrophil emigration and metabolic activity in lobar pneumonia and bronchiectasis.
复制标题
大叶性肺炎和支气管扩张中中性粒细胞迁移和代谢活动的分离。
DOI：
10.1183/09031936.97.10040795
复制
发表时间：
1997
期刊：
影响因子：
--
通讯作者：
C. Haslett
中科院分区：
文献类型：
--
作者：
H. Jones;S. Sriskandan;A. Peters;N. Pride;T. Krausz;A. Boobis;C. Haslett
In animal models of pulmonary inflammation, neutrophils exhibit a dramatic influx of glucose in periods of high metabolic activity. This information was utilized to develop a technique, involving positron emission tomography (PET) of 2-[18F]-fluoro-2-deoxy-D-glucose (18FDG), which measures neutrophil activity in situ. This technique was applied in a comparative study of neutrophil function in patients with acute lobar pneumonia or bronchiectasis. Neutrophil emigration was measured by gamma-scintigraphy of intravenously injected 111In-labelled granulocytes and neutrophil activity determined by PET of 18FDG. Neutrophil emigration was evident in 4 out of 5 bronchiectasis patients, whilst no emigration was apparent in the two pneumonia patients studied, consistent with animal studies showing maximum emigration soon after challenge. In contrast, 18FDG uptake was markedly increased in 4 out of 5 pneumonia patients but not in the patients with bronchiectasis. Localization of radioactivity to neutrophils was confirmed by microautoradiography of lavage fluid in a patient with pneumonia. These results suggest that the elevated uptake of glucose by neutrophils during the inflammatory response is a postmigratory event, most likely reflecting the respiratory burst, and that high levels of neutrophil emigration are not necessarily associated with significantly increased metabolic activity of these cells.
肺部炎症中的单核细胞保留和迁移。
DOI：
--
发表时间：
1988
期刊：
Laboratory investigation; a journal of technical methods and pathology
影响因子：
--
作者：
Doherty,DE;Downey,GP;Worthen,GS;Haslett,C;Henson,PM
通讯作者：
Henson,PM
DOI：
10.1164/ajrccm/144.2.254
发表时间：
1991-08-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
MARTIN, TR;PISTORESE, BP;MAUNDER, RJ
通讯作者：
MAUNDER, RJ
DOI：
10.1164/ajrccm/140.3.756
发表时间：
1989-09-01
期刊：
AMERICAN REVIEW OF RESPIRATORY DISEASE
影响因子：
--
作者：
HASLETT, C;SHEN, AS;CHERNIACK, RM
通讯作者：
CHERNIACK, RM