RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
RNA m6A methylation and MDSCs: Roles and therapeutic implications for radiotherapy.
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DOI：
10.1016/j.medj.2023.09.001
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发表时间：
2023-12
期刊：
影响因子：
17
通讯作者：
Liangliang Wang;R. Katipally;H. Liang;Kaiting Yang;S. Pitroda;Chuan He;Ralph R Weichselbaum
中科院分区：
文献类型：
--
作者：
Liangliang Wang;R. Katipally;H. Liang;Kaiting Yang;S. Pitroda;Chuan He;Ralph R Weichselbaum
新出现的证据表明，局部肿瘤放疗重塑了循环髓源性抑制细胞（MDSC）的库，并导致其浸润到肿瘤微环境中，这对放疗疗效构成了主要障碍。最近的研究发现，RNA m6A修饰在抗肿瘤免疫和辐射反应的关系。在这里，我们研究了这种RNA修饰调节辐射重塑肿瘤微环境的免疫环境的机制。我们讨论了针对m6A机制的潜在治疗干预措施，以改善放射治疗反应。
Emerging evidence suggests that local tumor radiotherapy reshapes the repertoire of circulating myeloid-derived suppressor cells (MDSCs) and leads to their infiltration into the tumor microenvironment, which poses a major obstacle for radiotherapy efficacy. Recent findings have identified RNA m6A modification at the nexus of both anti-tumor immunity and radiation response. Here, we examine the mechanisms by which this RNA modification modulates the immune milieu of the radiation-remodeled tumor microenvironment. We discuss potential therapeutic interventions targeting m6A machinery to improve radiotherapy response.