Silica Nanoparticles Functionalized with Zwitterionic Sulfobetaine Siloxane for Application as a Versatile Antifouling Coating System
Silica Nanoparticles Functionalized with Zwitterionic Sulfobetaine Siloxane for Application as a Versatile Antifouling Coating System
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DOI：
10.1021/acsami.7b04840
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发表时间：
2017-06-07
影响因子：
9.5
通讯作者：
Molino, Paul J.
中科院分区：
文献类型：
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作者：
Knowles, Brianna R.;Wagner, Pawel;Molino, Paul J.
对开发能够有效抵抗生物污染的表面的日益增长的需求导致了对具有潜在抗生物污染性能的纳米材料的广泛研究。然而，有效的涂层的制备受到活性表面官能团的可用性以及我们在材料界面处仔细控制和组织化学的能力的限制。在这里，我们提出了两种方法，通过反应的二氧化硅纳米粒子悬浮液和预沉积的二氧化硅纳米粒子膜与两性离子磺基甜菜碱（SB）制备亲水性低污染的表面涂层。二氧化硅纳米粒子悬浮液功能化与SB跨越三个pH条件和沉积作为薄膜通过一个简单的旋涂过程中产生亲水性的亲水性涂层。此外，通过暴露于两性离子溶液，预沉积的二氧化硅纳米颗粒的涂层被表面官能化。采用具有耗散监测的石英晶体微重力法作为用于监测和优化二氧化硅纳米颗粒表面的反应的高通量技术。纳米颗粒膜的功能化是快速的，并且可以在宽的pH范围内和在低的两性离子浓度下实现。所有功能化的颗粒表面呈现出高度的润湿性，并导致牛血清白蛋白蛋白的吸附量大幅减少。颗粒涂层还显示出真菌孢子（黑附球菌）和细菌（大肠杆菌）的粘附分别减少高达87%和96%。这些结果表明，功能化纳米二氧化硅的潜力，进一步开发为通用防污涂料广泛的涂料应用。
The growing need to develop surfaces able to effectively resist biological fouling has resulted in the widespread investigation of nanomaterials with potential antifouling properties. However, the preparation of effective antifouling coatings is limited by the availability of reactive surface functional groups and our ability to carefully control and organize chemistries at a materials interface. Here, we present two methods of preparing hydrophilic low-fouling surface coatings through reaction of silica-nanoparticle suspensions and predeposited silica-nanoparticle films with zwitterionic sulfobetaine (SB). Silica-nanoparticle suspensions were functionalized with SB across three pH conditions and deposited as thin films via a simple spin-coating process to generate hydrophilic antifouling coatings. In addition, coatings of predeposited silica nanoparticles were surface functionalized via exposure to zwitterionic solutions. Quartz crystal microgravimetry with dissipation monitoring was employed as a high throughput technique for monitoring and optimizing reaction to the silica-nanoparticle surfaces. Functionalization of nanoparticle films was rapid and could be achieved over a wide pH range and at low zwitterion concentrations. All functionalized particle surfaces presented a high degree of wettability and resulted in large reductions in adsorption of bovine serum albumin protein. Particle coatings also showed a reduction in adhesion of fungal spores (Epicoccum nigrum) and bacteria (Escherichia coli) by up to 87 and 96%, respectively. These results indicate the potential for functionalized nanosilicas to be further developed as versatile fouling-resistant coatings for widespread coating applications.