Thinking Outside the Heart: Use of Engineered Cardiac Tissue for the Treatment of Chronic Deep Venous Insufficiency.
Thinking Outside the Heart: Use of Engineered Cardiac Tissue for the Treatment of Chronic Deep Venous Insufficiency.
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DOI：
10.1177/1074248413520343
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发表时间：
2014-07
影响因子：
2.6
通讯作者：
Sarvazyan N
中科院分区：
文献类型：
--
作者：
Sarvazyan N
本文考虑使用自体干细胞来源的心肌细胞作为一种新的手段来帮助静脉回流。该方法包括在瓣膜功能不全或功能差的静脉段周围制造工程心脏组织的外部袖口。工程心脏组织袖带防止受损静脉段的扩张，并通过其有节奏的收缩帮助单向流动。这种方法似乎没有根本的限制，因为已经显示了所有单个组件的可行性。在这里，我们强调了治疗慢性深静脉功能不全的新方法的临床需求，回顾了以前的研究，考虑了工程心脏组织袖口的潜在设计，并概述了其优势和未来的挑战。
This article considers the use of autologous stem cell-derived cardiomyocytes as a novel means to aid venous return. The approach consists of creating external cuffs of engineered heart tissue around vein segments with incompetent or poorly competent valves. The engineered heart tissue cuff prevents distention of the impaired vein segments and aids unidirectional flow by its rhythmic contractions. There appear to be no fundamental limitations to this approach as feasibility of all of the individual components has already been shown. Here, we underline the clinical need for novel ways to treat chronic deep venous insufficiency, review previous research that enabled this approach, consider potential designs of engineered heart tissue cuffs, and outline its advantages and future challenges.
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影响因子：
15.9
作者：
Didie, Michael;Christalla, Peter;Zimmermann, Wolfram-Hubertus
通讯作者：
Zimmermann, Wolfram-Hubertus
影响因子：
6
作者：
Laflamme, MA;Gold, J;Murry, CE
通讯作者：
Murry, CE
影响因子：
1.5
作者：
Eschenhagen, T;Didié, M;Zimmermann, WH
通讯作者：
Zimmermann, WH
DOI：
10.1111/j.1527-5299.2005.04474.x
发表时间：
2005-07-01
期刊：
Congestive heart failure (Greenwich, Conn.)
影响因子：
--
作者：
Kar, Biswajit;Delgado, Reynolds M 3rd;Harting, Matthew T
通讯作者：
Harting, Matthew T
影响因子：
64.8
作者：
Laflamme, Michael A.;Murry, Charles E.
通讯作者：
Murry, Charles E.