Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling
Expression of TLE3 by bone marrow stromal cells is regulated by canonical Wnt signaling
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DOI：
10.1016/j.febslet.2013.12.031
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发表时间：
2014-02-14
期刊：
影响因子：
3.5
通讯作者：
Yoda, Tetsuya
中科院分区：
文献类型：
--
作者：
Kokabu, Shoichiro;Sato, Tsuyoshi;Yoda, Tetsuya
分裂信号转导样增强子3（Transducing-like enhancer of split 3，TLE 3）是Groucho/TLE家族成员之一，靶向Runx 2转录并抑制骨髓基质细胞（BMSCs）成骨细胞分化。在这里，我们通过比较基因组和功能分析确定TLE 3启动子区的Wnt响应元件，并表明TLE 3的表达通过Wnt信号传导增加，这对成骨细胞分化很重要。我们还证明了TLE 3能够抑制BMSC中的经典Wnt信号传导。总之，我们的数据表明，TLE 3的Wnt信号的诱导是成骨细胞分化过程中的负反馈回路的一部分。(C)2014年欧洲生物化学学会联合会。Elsevier B. V.出版，保留所有权利。
Transducing-like enhancer of split 3 (TLE3), one of the Groucho/TLE family members, targets Runx2 transcription and suppresses osteoblast differentiation in bone marrow stromal cells (BMSCs). Here, we identify Wnt responsive elements of the TLE3 promoter region through comparative genomic and functional analyses and show that expression of TLE3 is increased by Wnt signaling, which is important for osteoblast differentiation. We also demonstrated that TLE3 is able to suppress canonical Wnt signaling in BMSCs. Taken together, our data suggest that induction of TLE3 by Wnt signaling is part of a negative feedback loop active during osteoblast differentiation. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.