Translation, cross-cultural adaptation and applicability of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS)
Translation, cross-cultural adaptation and applicability of the Brazilian version of the Frontotemporal Dementia Rating Scale (FTD-FRS)
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DOI：
10.1590/s1980-57642013dn74000006
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发表时间：
2013-12-01
期刊：
影响因子：
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通讯作者：
Yassuda, Mônica Sanches
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文献类型：
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作者：
Lima-Silva, Thais Bento;Bahia, Valéria Santoro;Yassuda, Mônica Sanches
背景：痴呆分期量表是为阿尔茨海默病（AD）分级而设计的，但不包括额颞叶变性（FTLD）的具体症状。 目的：将额颞叶痴呆评定量表（FTD-FRS）翻译成巴西葡萄牙语并进行调整。 方法：跨文化适应过程包括以下步骤：翻译、回译（由独立翻译人员准备）、与专家讨论、以及经过细微调整后制定最终版本。对 12 名诊断为 bvFTD 的患者和 11 名诊断为 AD 的患者进行了试点应用，并与疾病严重程度相匹配 (CDR=1.0)。评估方案包括：阿登布鲁克认知检查修订版 (ACE-R)、简易精神状态检查 (MMSE)、行政访谈 (EXIT-25)、神经精神量表 (NPI)、额颞叶痴呆评定量表 (FTD-FRS) 和临床痴呆评定量表 (CDR)。 结果：巴西版本的 FTD-FRS 似乎适合在该国使用。初步结果显示，bvFTD 患者的残疾程度高于 AD 患者（bvFTD：25% 轻度、50% 中度和 25% 重度；AD：36.36% 轻度、63.64% 中度）。 CDR 似乎低估了 bvFTD 的疾病严重程度，因为根据 FTD-FRS，被评定为轻度痴呆 (CDR=1.0) 的患者的相关比例实际上患有中度或重度残疾。结论：巴西版本的 FTD-FRS 似乎适合帮助分期和确定疾病进展。
BACKGROUND: Staging scales for dementia have been devised for grading Alzheimer's disease (AD) but do not include the specific symptoms of frontotemporal lobar degeneration (FTLD).OBJECTIVE: To translate and adapt the Frontotemporal Dementia Rating Scale (FTD-FRS) to Brazilian Portuguese.METHODS: The cross-cultural adaptation process consisted of the following steps: translation, back-translation (prepared by independent translators), discussion with specialists, and development of a final version after minor adjustments. A pilot application was carried out with 12 patients diagnosed with bvFTD and 11 with AD, matched for disease severity (CDR=1.0). The evaluation protocol included: Addenbrooke's Cognitive Examination-Revised (ACE-R), Mini-Mental State Examination (MMSE), Executive Interview (EXIT-25), Neuropsychiatric Inventory (NPI), Frontotemporal Dementia Rating Scale (FTD-FRS) and Clinical Dementia Rating scale (CDR).RESULTS: The Brazilian version of the FTD-FRS seemed appropriate for use in this country. Preliminary results revealed greater levels of disability in bvFTD than in AD patients (bvFTD: 25% mild, 50% moderate and 25% severe; AD: 36.36% mild, 63.64% moderate). It appears that the CDR underrates disease severity in bvFTD since a relevant proportion of patients rated as having mild dementia (CDR=1.0) in fact had moderate or severe levels of disability according to the FTD-FRS.CONCLUSION: The Brazilian version of the FTD-FRS seems suitable to aid staging and determining disease progression.