Gender and age groups interactions in the quantification of bone marrow fat content in lumbar spine using 3T MR spectroscopy: A multivariate analysis of covariance (Mancova)
Gender and age groups interactions in the quantification of bone marrow fat content in lumbar spine using 3T MR spectroscopy: A multivariate analysis of covariance (Mancova)
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DOI：
10.1016/j.ejrad.2013.07.012
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发表时间：
2013-11-01
影响因子：
3.3
通讯作者：
Rios, Camilo
中科院分区：
文献类型：
--
作者：
Roldan-Valadez, Ernesto;Pina-Jimenez, Carlos;Rios, Camilo
简介：在中轴骨中，红色骨髓向黄色骨髓的转换与年龄有关，而与性别有关的差异则不太确定。本研究的目的是探讨腰椎骨髓脂肪分数（bone marrow fat fraction，FF）的性别和年龄差异。男20例，30-65岁，女24例，30-69岁，行腰椎3 T磁共振波谱（MRS）及常规MRI检查;采集每个椎体（VB）的单体素光谱。在控制体重指数（BMI）后，采用双向组间多变量协方差分析（MANCOVA）评估每个腰椎VB的FF定量的性别和年龄组差异。结果：性别和年龄组之间存在显著的相互作用，p = 0.017，效应量较大（偏eta（2）= 0.330）。然而，相互作用仅解释了观察到的方差的33%。主效应无统计学显著性。体重指数是非显着相关的FF quantitation.Conclusions：年轻男性表现出较高的FF含量，下降在第4个十年，然后增加了未来的30年，以达到FF含量略低于初始FF手段。女性的FF在第30年较低，描述了在第40年加速增加，然后在接下来的30年逐渐增加，达到与男性的FF值相似的含量。我们的研究结果表明，使用MRS定量骨髓FF可用作临床环境中骨髓活性的替代生物标志物。(C)2013爱思唯尔爱尔兰有限公司版权所有。
Introduction: There is an age-related conversion of red to yellow bone marrow in the axial skeleton, with a gender-related difference less well established. Our purpose was to clarify the variability of bone marrow fat fraction (FF) in the lumbar spine due to the interaction of gender and age groups.Methods: 44 healthy volunteers (20 males, 30-65 years old and 24 females, 30-69 years old) underwent 3T magnetic resonance spectroscopy (MRS) and conventional MRI examination of the lumbar spine; single-voxel spectrum was acquired for each vertebral body (VB). After controlling body mass index (BMI), a two-way between-groups multivariate analysis of covariance (MANCOVA) assessed the gender and age group differences in FF quantification for each lumbar VB.Results: There was a significant interaction between gender and age group, p = .017, with a large effect size (partial eta(2) = .330). However the interaction explained only 33% of the observed variance. Main effects were not statistically significant. BMI was non-significantly related to FF quantification.Conclusions: Young males showed a high FF content, which declined in the 4th decade, then increased the next 3 decades to reach a FF content just below the initial FF means. Females' FF were low in the 3rd decade, depicted an accelerated increase in the 4th decade, then a gradual increase the next 3 decades to reach a FF content similar to males' values. Our findings suggest that quantification of bone marrow FF using MRS might be used as a surrogate biomarker of bone marrow activity in clinical settings. (C) 2013 Elsevier Ireland Ltd. All rights reserved.