Changes in stiffness of demineralized dentin following application of collagen crosslinkers
Changes in stiffness of demineralized dentin following application of collagen crosslinkers
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DOI：
10.1002/jmb.b.31022
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发表时间：
2008-08-01
影响因子：
3.4
通讯作者：
Miescke, Klaus J.
中科院分区：
文献类型：
--
作者：
Bedran-Russo, Ana Karina B.;Pashley, David H.;Miescke, Klaus J.
据认为，使用交联剂增加牙本质基质的强度可以改善树脂-牙本质结合的强度和耐久性。本研究的目的是评价两种胶原交联剂（戊二醛，GD和葡萄籽提取物，GSE）对脱矿牙本质弹性模量的影响。根据交联剂的种类和浓度将完整的磨牙碎片完全脱矿并分为5组：2.5%GD、5%GD、25%GD、0.65%GSE、6.5%GSE。将样本浸入各自的溶液中，并在基线、10 min、30 min、1 h、2 h、4 h进行测试。牙本质的弹性模量受处理（p < 0.01）和暴露时间（p < 0.01）的影响。评价的两个因素之间存在统计学显著的相互作用（治疗vs.时间p < 0.01）。平均基线值在4.8和6.2 MPa之间变化，在水中，4小时的治疗后，值增加34.9和242.5 MPa之间，这是治疗时间和代理依赖。使用这些胶原交联剂来增加脱矿牙本质的刚度，是浓度和时间依赖性的。(c)2007 Wiley Periodicals，Inc.
It is thought that increasing the strength of the dentin matrix using crosslinking agents may improve both the strength and the durability of resin-dentin bonds. The purpose of this study was to evaluate the effect of two collagen crosslinking agents (glutaraldehyde, GD and grape seed extract, GSE) on the modulus of elasticity of demineralized dentin. Sound molar fragments were fully demineralized and divided into five groups according to the type and concentration of crosslinking agents: 2.5% GD; 5% GD, 25% GD; 0.65% GSE; 6.5% GSE. Specimens were immersed in their respective solution and tested at baseline, 10 min, 30 min, 1 h, 2 h, 4 h. The elastic modulus of dentin was significantly affected by the treatment (p < 0.01) and exposure time (p < 0.01). There was a statistically significant interaction between the two factors evaluated (treatment vs. time p < 0.01). Mean baselines values varied between 4.8 and 6.2 MPa in water; after 4 h of treatment the values increased between 34.9 and 242.5 MPa, that were treatment time and agent dependent. The use of these collagen crosslinkers to increase the stiffness of demineralized dentin, was both concentration and time dependent. (c) 2007 Wiley Periodicals, Inc.