The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal
The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal
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DOI：
10.1016/j.jep.2006.04.010
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发表时间：
2006-11-03
影响因子：
5.4
通讯作者：
Araujo, M. E. M.
中科院分区：
文献类型：
--
作者：
Ferreira, A.;Proenca, C.;Araujo, M. E. M.
精油，乙醇提取物和水煎液的10种植物从葡萄牙内地进行了分析，其对乙酰胆碱酯酶（ACNE）酶的活性和抗氧化活性。其中，香蜂草、银甲草、地榆、波叶金丝桃和锦葵用于草药，月桂和薄荷用作调味品，鼠尾草、熏衣草和熏衣草也用作芳香剂。香蜂草和薄荷精油对痤疮的抑制率超过50%。月桂、波叶金丝桃和地榆乙醇提取物对ACNE的抑制率分别为64%（1 mg·ml ~（-1））、68%（0.5mg·ml ~（-1））和78%（1 mg·ml ~（-1））。较高的值的痤疮抑制活性，发现使用熏衣草pedunculata，薄荷和金丝桃，68，69和82%（在5毫克干植物ml-1的测定浓度），分别提取物。极性提取物的自由基清除活性较高。在水提取物中，大多数植物显示90%左右的值。当用β-胡萝卜素-亚油酸试验测量抗氧化活性时，在水提取物中也发现高活性（65-95%）。波叶金丝桃、香蜂花和月桂表现出较高的抗氧化活性和抑制痤疮的能力。(c)2006爱思唯尔爱尔兰有限公司保留所有权利。
Essential oil, ethanolic extract and decoction of 10 plant species from interior Portugal were analyzed for their activity towards acetylcholinesterase (ACNE) enzyme and their antioxidant activity. Of these, Melissa officinalis, Paronychia argentea, Sanguisorba minor, Hypericum undulatum and Malva silvestris are used in herbal medicine, Laurus nobilis and Mentha suaveolens as condiments, and Salvia officinalis, Lavandula angustifolia and Lavandula pedunculata also as aromatics. Melissa officinalis and Mentha suaveolens showed ACNE inhibitory capacity higher then 50% in the essential oil fraction. Laurus nobilis, Hypericum undulatum, and Sanguisorba minor showed a high inhibition value of ACNE in the ethanolic fraction, 64% (1 mg ml(-1)) 68% (0.5 mg ml(-1)), and 78% (1 mg ml(-1)), respectively. Higher values of ACNE inhibitory activity were found using decoctions of Lavandula pedunculata, Mentha suaveolens and Hypericum undulatum, 68, 69 and 82% (at a concentration of 5 mg dry plant ml-1 of assay), respectively. The free radical scavenger activity was higher for the polar extracts. In the water extracts most of the plants showed values around 90%. When antioxidant activity was measured with the beta-carotene-linoleic acid assay high activity (65-95%) was also found in the water extracts. Hypericum undulatum, Melissa officinalis and Laurus nobilis showed both high ACNE inhibitory capacity and antioxidant activity. (c) 2006 Elsevier Ireland Ltd. All rights reserved.