Recurrent crystal-storing histiocytosis of the lung in a patient without a clonal lymphoproliferative disorder.
Recurrent crystal-storing histiocytosis of the lung in a patient without a clonal lymphoproliferative disorder.
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无克隆性淋巴增殖性疾病的患者患有复发性肺晶体储存组织细胞增多症。
DOI：
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发表时间：
1996
影响因子：
4.6
通讯作者：
A. Renshaw
中科院分区：
文献类型：
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作者：
D. Jones;A. Renshaw
一名 54 岁女性出现无症状的孤立性肺部肿块，切除后 10 年后复发。两种病变均由肺泡内和间质巨噬细胞的局部聚集组成，其中充满大量嗜酸性细胞质晶体。该晶体是非双折射的、高碘酸席夫阴性的，并且与κ和λ轻链以及α、μ和γ重链表现出多型反应。没有检测到免疫球蛋白基因重排。这种病变与晶体储存组织细胞增多症一致，据报道这与浆细胞瘤有关。然而，在这种情况下，晶体或周围浆细胞内不存在单型免疫球蛋白染色，不存在DNA重排，并且长期无症状病程增加了这种病变可能是反应性的可能性。在免疫缺陷小鼠的肺部也发现了类似的病变。晶体储存组织细胞增多症可能代表了对过量免疫球蛋白的一般反应模式。
A 54-year-old woman developed an asymptomatic solitary lung mass, which recurred 10 years after resection. Both lesions consisted of a localized collection of intra-alveolar and interstitial macrophages filled with numerous eosinophilic cytoplasmic crystals. The crystals were non-birefringent, periodic acid-Schiff-negative, and showed polytypic reaction with both kappa and lambda light chains, and alpha, mu, and gamma heavy chains. No immunoglobulin gene rearrangements were detected. This lesion is consistent with crystal-storing histiocytosis, which has been reported in association with plasmacytoma. However, in this case, the absence of monotypic immunoglobulin staining within the crystals or the surrounding plasma cells, the absence of DNA rearrangements, and the long asymptomatic course raise the possibility that this lesion may be reactive. Similar lesions are seen in the lungs of mice with immune defects. Crystal-storing histiocytosis may represent a general reaction pattern to excess immunoglobulin.