Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis.
Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis.
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DOI：
10.1016/s0140-6736(10)60206-1
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发表时间：
2010-05-01
期刊：
影响因子：
168.9
通讯作者：
Campbell, Harry
中科院分区：
文献类型：
--
作者：
Nair, Harish;Nokes, D. James;Gessner, Bradford D.;Dherani, Mukesh;Madhi, Shabir A.;Singleton, Rosalyn J.;O'Brien, Katherine L.;Roca, Anna;Wright, Peter F.;Bruce, Nigel;Chandran, Aruna;Theodoratou, Evropi;Sutanto, Agustinus;Sedyaningsih, Endang R.;Ngama, Mwanajuma;Munywoki, Patrick K.;Kartasasmita, Cissy;Simoes, Eric A. F.;Rudan, Igor;Weber, Martin W.;Campbell, Harry
呼吸道合胞病毒（RSV）引起的全球疾病负担仍然未知。我们的目的是估计2005年5岁以下儿童因RSV引起的急性下呼吸道感染（ALRI）的全球发病率和死亡率。我们对1995年1月至2009年6月发表的研究和10项未发表的基于人群的研究进行了系统回顾，并根据年龄分层，估计了5岁以下儿童中RSV相关ALRI的发病率。我们通过将病死率与已发表和未发表研究中基于医院报告的发病率估计值相结合，并确定具有RSV季节性和每月ALRI死亡率的基于人群数据的研究，估计了RSV相关ALRI死亡率的可能界限。2005年，估计全球5岁以下儿童新发3380万（95% CI 19.3 - 46.2）万例RSV相关ALRI（占ALRI发作的22%），其中至少340万（2.8 - 4.3）万例严重RSV相关ALRI需要住院。我们估计，2005年有66000 - 199000名5岁以下儿童死于RSV相关ALRI，其中99%发生在发展中国家。 在任何一种情况下，发病率和死亡率每年都有很大的不同。在全球范围内，RSV是儿童ALRI的最常见原因，也是因重度ALRI而入院的主要原因。死亡率数据表明，RSV是儿童ALRI死亡的一个重要原因，仅次于肺炎球菌性肺炎和流感嗜血杆菌B型。应优先加快制定新的预防和治疗战略。比尔和梅林达·盖茨基金会。
The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. In 2005, an estimated 33·8 (95% CI 19·3–46·2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3·4 (2·8–4·3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000–199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. WHO; Bill & Melinda Gates Foundation.