Neurocognition in bipolar disorders-A closer look at comorbidities and medications
Neurocognition in bipolar disorders-A closer look at comorbidities and medications
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DOI：
10.1016/j.ejphar.2009.10.018
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发表时间：
2010-01-10
影响因子：
5
通讯作者：
Tabares-Seisdedos, Rafael
中科院分区：
文献类型：
--
作者：
Balanza-Martinez, Vicent;Selva, Gabriel;Tabares-Seisdedos, Rafael
在过去的十年里，人们对双相情感障碍(BD)的神经心理学研究越来越感兴趣。这种慢性情绪障碍与持续的神经认知障碍有关，即使在欣快期也是如此，特别是在注意力、言语记忆和执行功能的广泛领域。更有趣的是，认知功能障碍似乎预示着BD患者较差的功能结局，因此是未来治疗的重要靶点。认知功能障碍的病因可能是多因素的，包括基因与环境的相互作用以及潜在的混杂变量。药物所致的认知不良反应是一个重要且难以检验的因素。本文综述了双相情感障碍患者神经认知的某些方面，重点介绍了药物以及内科和精神科并存疾病对认知功能障碍的相对贡献。最后，对该领域未来的研究提出了建议，包括更大样本的合作研究、观察性随访研究以及比较不同药物对神经认知影响的随机临床试验。(C)2009爱思唯尔B.V.保留所有权利。
The last decade has witnessed a growing interest in the neuropsychological study of bipolar disorder (BD). This chronic mood disorder is associated with persistent neurocognitive impairments even during periods of euthymia, particularly in the broad domains of attention, verbal memory and executive functions. More interestingly, cognitive dysfunction seems to predict a poorer functional outcome among BD patients and thus represents an important target for future therapies. The aetiology of cognitive dysfunction is probably multifactorial, including gene-environment interactions with potentially confounding variables as well. Drug-induced cognitive adverse effects represent an important and difficult to examine confounder. This review provides an overview of selected aspects of neurocognition in bipolar disorder with a focus on the relative contributions of medications as well as medical and psychiatric comorbid conditions to cognitive dysfunction. Finally, recommendations for future research in the field are provided including collaborative studies with larger samples, observational follow-up studies, as well as randomized clinical trials comparing head-to-head the neurocognitive impact of different medications. (C) 2009 Elsevier B.V. All rights reserved.