Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States.
Multiple reassortment between pandemic (H1N1) 2009 and endemic influenza viruses in pigs, United States.
复制标题
DOI：
10.3201/eid1709.110338
复制
发表时间：
2011-09
影响因子：
11.8
通讯作者：
Webby RJ
中科院分区：
文献类型：
--
作者：
Ducatez MF;Hause B;Stigger-Rosser E;Darnell D;Corzo C;Juleen K;Simonson R;Brockwell-Staats C;Rubrum A;Wang D;Webb A;Crumpton JC;Lowe J;Gramer M;Webby RJ
TOC总结：属于这些新基因型的病毒与地方性猪病毒在表型上无法区分。由于人与猪之间的传播，2009年甲型H1N1流感病毒在人身上出现后不久就在猪身上被发现。在美国，这种传播之后很快发生了大流行性病毒和地方性猪病毒之间的多重重配。在美国的商业猪场中检测到代表7种基因型的9种重传病毒。现场观察表明，新描述的reflectant病毒与2009年大流行（H1N1）或地方性毒株在致病能力方面没有实质性差异。在体外的reflectant和地方性病毒的可比生长特性支持这些观察结果;同样，一个代表性的reflectant病毒在雪貂中复制的程度与2009年大流行（H1N1）和地方性猪病毒相同。这些新的病毒突出了猪群中流感病毒的复杂性增加，以及在这个生态重要的病毒库中病毒多样化发生的频率。
TOC Summary: Viruses belonging to these novel genotypes are indistinguishable phenotypically from endemic swine viruses. As a result of human-to-pig transmission, pandemic influenza A (H1N1) 2009 virus was detected in pigs soon after it emerged in humans. In the United States, this transmission was quickly followed by multiple reassortment between the pandemic virus and endemic swine viruses. Nine reassortant viruses representing 7 genotypes were detected in commercial pig farms in the United States. Field observations suggested that the newly described reassortant viruses did not differ substantially from pandemic (H1N1) 2009 or endemic strains in their ability to cause disease. Comparable growth properties of reassortant and endemic viruses in vitro supported these observations; similarly, a representative reassortant virus replicated in ferrets to the same extent as did pandemic (H1N1) 2009 and endemic swine virus. These novel reassortant viruses highlight the increasing complexity of influenza viruses within pig populations and the frequency at which viral diversification occurs in this ecologically important viral reservoir.