4-Hydroxy-2-nonenal: a critical target in oxidative stress?
4-Hydroxy-2-nonenal: a critical target in oxidative stress?
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4-羟基-2-壬烯醛：氧化应激的关键靶点？
DOI：
10.1152/ajpcell.00101.2016
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发表时间：
2016-10-01
影响因子：
5.5
通讯作者：
Kolliputi, Narasaiah
中科院分区：
文献类型：
--
作者：
Breitzig, Mason;Bhimineni, Charishma;Kolliputi, Narasaiah
从这个角度来看，我们总结并讨论了4-羟基-2-壬烯醛（4-HNE）研究的重要进展，因为它与氧化应激引起或加剧的疾病和临床并发症有关。自1980年鉴定以来，4-HNE已被广泛研究，重点是其形成，其在病理学中的作用及其靶点。作为一种活性醛和脂质过氧化的产物，研究证实其能够破坏信号转导和蛋白质活性，以及在氧化应激条件下诱导炎症和触发细胞凋亡。值得注意的是，我们讨论了参与4-HNE调节的天然酶的作用，以及它们如何在各种生理条件下应用于其解毒。
In this perspective, we summarize and discuss critical advancements in the study of 4-hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or exacerbated by oxidative stress. Since its identification in 1980, 4-HNE has been extensively studied with an emphasis on its formation, its role in pathology, and its targets. As a reactive aldehyde, and a product of lipid peroxidation, studies corroborate its ability to disrupt signal transduction and protein activity, as well as induce inflammation and trigger cellular apoptosis in conditions of oxidative stress. Notably, we discuss the role of natural enzymes involved in the regulation of 4-HNE, and how they can be applied to its detoxification in various physiological conditions.