Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice
Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice
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DOI：
10.1016/j.canlet.2008.04.026
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发表时间：
2008-09-28
期刊：
影响因子：
9.7
通讯作者：
El-Sayed, Mostafa A.
中科院分区：
文献类型：
--
作者：
Dickerson, Erin B.;Dreaden, Erik C.;El-Sayed, Mostafa A.
等离子体光热疗法(PPTT)是一种微创的肿瘤治疗策略，它选择性地给予光子能量，并将其转化为足以引起细胞高温的热量。本工作证明了使用易于制备的等离子体金纳米棒和小型、便携、廉价的近红外(NIR)激光进行PPTT治疗深部组织恶性肿瘤的可行性。在nu/nu小鼠中，直接(P<；0.0001)和静脉(P<；0.0008)给药的聚乙二醇化金纳米棒在鳞状细胞癌异种移植瘤中观察到显著的尺寸减小。在13天的时间里，观察到两种给药方法的平均肿瘤生长受到抑制，57%的直接注射的肿瘤和25%的静脉治疗的肿瘤被吸收。爱思唯尔有限公司出版。
Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P < 0.0001) and intravenous (P < 0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors. Published by Elsevier Ltd.