Optimal gestational weight gain to reduce the risk of hypertension disorders of pregnancy among women with obesity: A single tertiary referral center study in Japan
Optimal gestational weight gain to reduce the risk of hypertension disorders of pregnancy among women with obesity: A single tertiary referral center study in Japan
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最佳妊娠体重增加可降低肥胖女性妊娠期高血压疾病的风险：日本的一项三级转诊中心研究
DOI：
10.1111/jog.15372
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Misa Sugeno and Hyo Kyozuka
中科院分区：
文献类型：
--
作者：
Iwahashi N;Ikezaki M;Komohara Y;Fujiwara Y;Noguchi T;Nishioka K;Sakai K;Nishio K;Ueda M;Ihara Y;Uchimura K;Ino K;Nishitsuji K;Misa Sugeno and Hyo Kyozuka
目的探讨孕前体重指数≥30.0 kg/m2的孕妇孕期体重增加对妊娠期高血压疾病的影响。方法回顾性队列研究包括257名日本妇女（116条第2款; 141例经产妇），单胎妊娠，孕前体重指数≥ 30.0 kg/m2，2013年至2020年在太田西之内医院分娩。进行多元Logistic回归分析，以确定妊娠期体重增加对早发性（<34周），晚发性（≥34周）和整体妊娠高血压疾病的影响。多因素Logistic回归分析显示，妊娠期体重增加可增加孕妇早发性高血压疾病（校正比值比：1.20，95%可信区间：1.03- 1.39，p < 0.05）和总体妊娠期高血压疾病（校正比值比：1.12，95%可信区间：1.03- 1.22，p < 0.05）的风险。基于早发型受试者工作特征曲线分析（曲线下面积0.67，95%可信区间：0.56-0.78;p< 0.05）和总体妊娠期高血压疾病（曲线下面积0.76，95%可信区间：0.61-0.91; p< 0.05）在妊娠期高血压疾病中，我们确定早发性和总体妊娠期高血压疾病的妊娠期体重增加临界值为3.85 kg，敏感性/特异性分别为0.76/0.59和0.91/0.53。这些信息可能有助于肥胖女性的个性化孕前咨询。
AimTo examine the effect of weight gain during pregnancy on hypertension disorders of pregnancy among women with a prepregnancy body mass index ≥30.0 kg/m2.MethodsThis retrospective cohort study included 257 Japanese women (116 primipara; 141 multipara) with singleton pregnancies with a prepregnancy body mass index ≥ 30.0 kg/m2, who gave birth during 2013 to 2020 at Ohta Nishinouchi Hospital. Multiple logistic regression analyses were performed to identify the effect of gestational weight gain on early‐onset (<34 weeks), late‐onset (≥34 weeks), and overall hypertension disorders of pregnancy.ResultsThe prevalence of hypertension disorders of pregnancy in primiparas and multiparas was 28.4% and 11.3%, respectively. By multiple logistic regression analysis, gestational weight gain during pregnancy increased the risk of early‐onset (adjusted odds ratio: 1.20, 95% confidence interval: 1.03–1.39,p< 0.05) and overall hypertension disorders of pregnancy (adjusted odds ratio: 1.12, 95% confidence interval: 1.03–1.22,p< 0.05) among primiparas. Based on receiver operating characteristic curve analyses for early‐onset (area under the curve 0.67, 95% confidence interval: 0.56–0.78;p< 0.05) and overall hypertension disorders of pregnancy (area under the curve 0.76, 95% confidence interval: 0.61–0.91;p< 0.05) among primiparas, we determined the cut‐off weight gain during pregnancy for early‐onset and overall hypertension disorders of pregnancy as 3.85 kg, with sensitivity/specificity of 0.76/0.59 and 0.91/0.53, respectively.ConclusionWe recommend that the optimal gestational weight gain for reducing HDP be under 3.85 kg. This information may facilitate personalized pre‐conception counseling among women with obesity.
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影响因子：
4.7
作者：
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影响因子：
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