Effects of putative satiety peptides on feeding and drinking behavior in golden hamsters (Mesocricetus auratus).
Effects of putative satiety peptides on feeding and drinking behavior in golden hamsters (Mesocricetus auratus).
复制标题
假定的饱腹感肽对金仓鼠（Mesocricetus auratus）进食和饮水行为的影响。
DOI：
10.1037//0735-7044.99.6.1192
复制
发表时间：
1985
影响因子：
1.9
通讯作者：
Malsbury,CW
中科院分区：
文献类型：
--
作者：
Miceli,MO;Malsbury,CW
进行了一系列实验以表征假定的饱腹感肽对叙利亚仓鼠进食的影响，叙利亚仓鼠是已知具有不同于其他动物的生理进食控制的物种。外周注射八肽胆囊收缩素（CCK-8）以剂量相关的方式减少仓鼠的摄食。CCK-8在减少雌性仓鼠的食物摄入量方面同样有效，在光照周期的亮和暗部分进行测试，但在亮部分进行测试的雄性中无效。全身注射丙谷胺（一种假定的CCK受体拮抗剂）并没有改变自发摄食量，也没有逆转外周注射CCK-8引起的摄食抑制。全身注射蛙皮素（BBS）、促甲状腺激素释放激素（TRH）和降钙素（CT）可产生剂量相关的摄食抑制。BBS似乎是专门这么做的。相反，TRH似乎通过暂时使动物虚弱来减少进食; CT通过唤起与进食不相容的行为（增加自发活动）来减少进食。侧脑室（icv）注射CCK-8，BBS和CT产生剂量相关的摄食抑制，但只有CCK-8出现选择性影响摄食行为。icv BBS后进食减少与过度梳理相关，icv CT与全身CT一样，增加了运动行为。这些发现在仓鼠的肽能控制在其他物种的饲养进行了讨论。
A series of experiments was conducted to characterize the effects of putative satiety peptides on feeding in the Syrian hamster, a species known to have physiological feeding controls different from those of other animals. Peripheral injections of cholecystokinin octapeptide (CCK-8) reduced feeding in hamsters in a dose-related fashion. CCK-8 was equally effective in reducing food intake in female hamsters tested during the light and dark portions of the illumination cycle but was ineffective in males tested during the light portion. Systemic injections of proglumide, a putative CCK receptor antagonist, did not alter spontaneous food intake and did not reverse the suppression of feeding resulting from peripheral CCK-8 injections. Systemic injections of bombesin (BBS), thyrotropin releasing hormone (TRH), and calcitonin (CT) produced a dose-related suppression of food intake. BBS appeared to do so specifically. In contrast, TRH appeared to reduce feeding by temporarily debilitating the animals; CT, by evoking behavior (increased locomotor activity) incompatible with feeding. Intracerebroventricular (icv) injections of CCK-8, BBS, and CT produced dose-related inhibition of feeding, but only CCK-8 appeared to affect feeding behavior selectively. Reduced feeding after icv BBS was associated with excessive grooming, and icv CT, like systemic CT, increased locomotor behavior. These findings in the hamster are discussed in relation to peptidergic control of feeding in other species.