Cognitive dysfunction in an urban Indian population - Some observations
Cognitive dysfunction in an urban Indian population - Some observations
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DOI：
10.1159/000146252
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发表时间：
2008-01-01
影响因子：
5.7
通讯作者：
Hazra, A.
中科院分区：
文献类型：
--
作者：
Banerjee, T. K.;Mukherjee, C. S.;Hazra, A.
在印度没有关于轻度认知障碍（MCI）的前瞻性研究。本研究旨在确定痴呆的患病率，并对一组轻度认知障碍患者进行前瞻性分析。在印度加尔各答进行了一项挨家挨户的横断面整群调查，调查对象是年龄在50岁至50岁之间的人，以估计痴呆症的患病率。然后连续4年对21名有记忆障碍的老年人进行年度认知功能评估。共有53,907人接受了调查。50岁和60岁痴呆的粗患病率分别为0.62% （95% CI 0.44-0.84）和1.25% （95% CI 0.87-1.74）。50岁以上人群的加权患病率为0.95% （95% CI 0.68 ~ 1.29）。阿尔茨海默病是最常见的亚型（55%），其次是血管性痴呆（36%）。在一项前瞻性研究中，MCI保持不变，转化为痴呆或恢复正常。MCI也有从一种亚型到另一种亚型的转变。西方国家也注意到MCI的类似结果。然而，东印度的痴呆症患病率仍然很低。版权所有2008 S. Karger AG，巴塞尔
There is no prospective study of mild cognitive impairment (MCI) in India. This study aims to determine the prevalence rate of dementia and to prospectively analyze a group of patients with MCI. A door-to-door cross-sectional cluster survey was conducted in Kolkata, India, among those aged >50 years to estimate the prevalence rate of dementia. Then annual assessment of cognitive function using a validated questionnaire battery was undertaken among 21 elderly individuals with memory complaints for 4 consecutive years. A total of 53,907 persons were surveyed. The crude prevalence rates of dementia were 0.62% (95% CI 0.44-0.84) and 1.25% (95% CI 0.87-1.74) among those >50 and >60 years of age, respectively. The weighted prevalence rate among those above 50 years was 0.95% (95% CI 0.68-1.29). Alzheimer's disease was the commonest subtype (55%) followed by vascular dementia (36%). In a prospective study, MCI remained static, converted to dementia or reverted to normalcy. There was also transition from one subtype of MCI to another. A similar outcome of MCI is also noted in Western nations. However, the prevalence rate of dementia in Eastern India remained quite low. Copyright (C) 2008 S. Karger AG, Basel.