The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria
The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria
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DOI：
10.1093/humrep/dep399
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发表时间：
2010-02-01
影响因子：
6.1
通讯作者：
Davies, Michael J.
中科院分区：
文献类型：
--
作者：
March, Wendy A.;Moore, Vivienne M.;Davies, Michael J.
多囊卵巢综合征（PCOS）被认为是育龄妇女中最常见的内分泌疾病，但关于适当的诊断标准和抽样方法的设计限制的争论使人们对社区的实际患病率产生了一些疑问。本研究的目的是根据美国国立卫生研究院（NIH）的标准、最近的鹿特丹共识标准和雄激素过量协会（AES）的标准，建立一个具有代表性的社区PCOS患病率估计值（年龄= 27-34岁; n = 728）。通过检查确定PCOS的症状（高雄激素血症、月经功能障碍和多囊卵巢），并对不同意接受超声检查的患者进行多囊卵巢插补。使用NIH标准，该出生队列中PCOS的估计患病率为8.7 ± 2.0%（无需插补）。根据鹿特丹标准，患病率为11.9 +/- 2.4%，当纳入插补数据时，患病率增加至17.8 +/- 2.8%。根据AES建议，PCOS患病率为10.2 +/-2.2%，插补数据为12.0 +/- 2.4%。在患有PCOS的妇女中，68-69%没有预先存在的诊断。鹿特丹和AES的患病率估计值是NIH标准的两倍，其他患病率研究也是如此。此外，这项研究还提请注意社区中许多患有PCOS的妇女未被诊断的问题。
Polycystic ovary syndrome (PCOS) is considered to be the most common endocrine disorder in women of reproductive age, yet debate over appropriate diagnostic criteria and design limitations with sampling methodology have left some doubt as to the actual prevalence in the community. The objective of this study was to create a representative prevalence estimate of PCOS in the community under the National Institutes of Health (NIH) criteria and the more recent Rotterdam consensus criteria and Androgen Excess Society (AES) criteria.A retrospective birth cohort study was carried out in which 728 women born during 1973-1975 in a single maternity hospital were traced and interviewed in adulthood (age = 27-34 year; n = 728). Symptoms of PCOS (hyperandrogenism, menstrual dysfunction and polycystic ovaries) were identified by examination and the presence of polycystic ovaries in those that did not consent to the ultrasound were imputed.The estimated prevalence of PCOS in this birth cohort using the NIH criteria was 8.7 +/- 2.0% (with no need for imputation). Under the Rotterdam criteria, the prevalence was 11.9 +/- 2.4% which increased to 17.8 +/- 2.8% when imputed data were included. Under the AES recommendations, PCOS prevalence was 10.2 +/- 2.2%, and 12.0 +/- 2.4% with the imputed data. Of the women with PCOS, 68-69% did not have a pre-existing diagnosis.The Rotterdam and AES prevalence estimates were up to twice that obtained with the NIH criteria in this, as well other prevalence studies. In addition, this study also draws attention to the issue of many women with PCOS in the community remaining undiagnosed.