Protocol for Pilot Study on Self-Management of Depressive Symptoms in Pregnancy.
Protocol for Pilot Study on Self-Management of Depressive Symptoms in Pregnancy.
复制标题
妊娠期抑郁症状自我管理试点研究方案。
DOI：
10.1097/nnr.0000000000000382
复制
发表时间：
2020
期刊：
影响因子：
2.5
通讯作者：
Starkweather,Angela
中科院分区：
文献类型：
--
作者：
Kinser,PatriciaA;Moyer,Sara;Mazzeo,Suzanne;York,TimothyP;Amstadter,Ananda;Thacker,Leroy;Starkweather,Angela
有抑郁症状的孕妇面临着巨大的治疗挑战，非常需要安全、有效、可及、廉价和非药物的自我管理疗法，以提高她们的幸福感，减轻怀孕期间和产后症状的负担，并预防慢性后遗症。在这篇文章中，我们描述了一项名为“正念妈妈”的自我管理干预试验研究的方案，该研究旨在培养女性应对当前抑郁症状的能力，并增强恢复力以防止复发。方法：我们将对有抑郁症状的孕妇进行为期12周的纵向先导试验（n= 40）；主要目的是确定干预的可行性和可接受性。次要目的是检查干预对妊娠期和产后6周产妇心理行为结果的初步影响。第三个目标是量化与怀孕期间抑郁症状相关的全基因组和基因特异性DNA甲基化模式，并研究干预参与是否会影响这些模式。结果
BackgroundPregnant women with depressive symptoms face significant treatment challenges and are in great need of safe, effective, accessible, inexpensive, and nonpharmacological self-management therapies to enhance well-being, reduce the burden of symptoms both during their pregnancy and postpartum, and prevent chronic sequelae.ObjectivesIn this article, we describe the protocol for our pilot study testing a self-management intervention entitled,“Mindful Moms,” designed to foster women’s ability to address current depressive symptoms and enhance resilience to prevent recurrence.MethodsWe will conduct a longitudinal pilot trial of the 12-week intervention with pregnant women with depressive symptoms (n= 40); the primary aim is to determine the feasibility and acceptability of the intervention. The secondary aim is to examine preliminary effects of the intervention on maternal psychobehavioral outcomes in pregnancy and 6 weeks postpartum. The third aim will quantify genome-wide and gene-specific DNA methylation patterns associated with depressive symptoms during pregnancy and investigate whether intervention participation influences these patterns.Results