Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.
Atypical Bilateral Brain Synchronization in the Early Stage of Human Voice Auditory Processing in Young Children with Autism.
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DOI：
10.1371/journal.pone.0153077
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发表时间：
2016
期刊：
影响因子：
3.7
通讯作者：
Minabe Y
中科院分区：
文献类型：
--
作者：
Kurita T;Kikuchi M;Yoshimura Y;Hiraishi H;Hasegawa C;Takahashi T;Hirosawa T;Furutani N;Higashida H;Ikeda T;Mutou K;Asada M;Minabe Y
自闭症谱系障碍（ASD）被认为与大规模神经网络中的神经元合作受损有关，包括皮质-皮质半球间回路。在ASD的背景下，外周和中枢听觉过程的改变也引起了极大的兴趣，因为这些变化似乎代表了病理生理过程；因此，许多先前的研究都集中在ASD的非典型听觉反应上。脑磁图记录的听觉诱发场（AEF）以及这些过程在左右脑半球之间的同步性最近被认为反映了儿童的各种认知能力。然而，到目前为止，还没有先前的研究关注ASD受试者的AEF同步。为了评估空间分布脑区域的全局协调性，提出了多通道神经生理数据的Omega复杂性分析。采用Omega复杂度分析，研究了3 - 8岁典型发育（TD）儿童（n = 50）和ASD儿童（n = 50）在50 ms时间窗内的AEFs全局协调性。在0-50 ms的时间窗内，ASD儿童的Omega复杂性明显高于TD儿童，提示P1m成分早期全脑同步较低。当我们分别分析左半球和右半球时，没有观察到任何时间窗的显著差异。这些结果表明，与TD儿童相比，ASD儿童的左右半球同步较低。我们的研究通过对人声的听觉诱发神经反应的研究，为ASD幼儿神经同步异常提供了新的证据。
Autism spectrum disorder (ASD) has been postulated to involve impaired neuronal cooperation in large-scale neural networks, including cortico-cortical interhemispheric circuitry. In the context of ASD, alterations in both peripheral and central auditory processes have also attracted a great deal of interest because these changes appear to represent pathophysiological processes; therefore, many prior studies have focused on atypical auditory responses in ASD. The auditory evoked field (AEF), recorded by magnetoencephalography, and the synchronization of these processes between right and left hemispheres was recently suggested to reflect various cognitive abilities in children. However, to date, no previous study has focused on AEF synchronization in ASD subjects. To assess global coordination across spatially distributed brain regions, the analysis of Omega complexity from multichannel neurophysiological data was proposed. Using Omega complexity analysis, we investigated the global coordination of AEFs in 3–8-year-old typically developing (TD) children (n = 50) and children with ASD (n = 50) in 50-ms time-windows. Children with ASD displayed significantly higher Omega complexities compared with TD children in the time-window of 0–50 ms, suggesting lower whole brain synchronization in the early stage of the P1m component. When we analyzed the left and right hemispheres separately, no significant differences in any time-windows were observed. These results suggest lower right-left hemispheric synchronization in children with ASD compared with TD children. Our study provides new evidence of aberrant neural synchronization in young children with ASD by investigating auditory evoked neural responses to the human voice.