Longitudinal study of resting energy expenditure, body cell mass and the inflammatory response in male patients with non-small cell lung cancer
Longitudinal study of resting energy expenditure, body cell mass and the inflammatory response in male patients with non-small cell lung cancer
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DOI：
10.1016/s0169-5002(00)00244-0
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发表时间：
2001-06-01
期刊：
影响因子：
5.3
通讯作者：
McArdle, CS
中科院分区：
文献类型：
--
作者：
Scott, HR;McMillan, DC;McArdle, CS
本研究的目的是检查非小细胞肺癌（NSCLC）患者体重减轻前后的炎症反应和静息能量消耗之间的相互关系。对健康受试者 (n = 7) 和体重未减轻的 NSCLC 患者 (n = 13) 进行了研究。根据体内钾总量测量，根据代谢活跃的组织调整静息能量消耗。 NSCLC 组的这一比例大约高出 15%（P < 0.01）。而且。静息能量消耗。与炎症反应的强度相关（v = 0.753。P < 0.01）。六名癌症患者随后体重减轻，静息能量消耗与炎症反应之间的关系得以维持。这些结果强调了非小细胞肺癌患者体重减轻之前炎症反应对静息能量消耗增加的影响。 (C) 2001 Elsevier Science Ireland Ltd. 保留所有权利。
The aim of this study was to examine the inter-relationship between the inflammatory response and resting energy expenditure in patients with non-small cell lung cancer (NSCLC) before and after the onset of weight loss. Healthy subjects (n = 7) and patients with NSCLC without weight loss (n = 13) were studied. Resting energy expenditure adjusted for metabolically active tissue, as measured by total body potassium. was approximately 15% higher in the NSCLC group (P < 0.01). Moreover. the resting energy expenditure. correlated with the magnitude of the inflammatory response (v = 0.753. P < 0.01). Six cancer patients subsequently lost weight and the relationship between resting energy expenditure and the inflammatory response was maintained. These results highlight the impact of the inflammatory response on the increase in the resting energy expenditure which precedes the onset of weight loss in patients with NSCLC. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.