Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
Genomic epidemiology of SARS-CoV-2 in a UK university identifies dynamics of transmission.
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DOI：
10.1038/s41467-021-27942-w
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发表时间：
2022-02-08
影响因子：
16.6
通讯作者：
Goodfellow IG
中科院分区：
文献类型：
--
作者：
Aggarwal D;Warne B;Jahun AS;Hamilton WL;Fieldman T;du Plessis L;Hill V;Blane B;Watkins E;Wright E;Hall G;Ludden C;Myers R;Hosmillo M;Chaudhry Y;Pinckert ML;Georgana I;Izuagbe R;Leek D;Nsonwu O;Hughes GJ;Packer S;Page AJ;Metaxaki M;Fuller S;Weale G;Holgate J;Brown CA;Cambridge Covid-19 testing Centre;University of Cambridge Asymptomatic COVID-19 Screening Programme Consortium;COVID-19 Genomics UK (COG-UK) Consortium;Howes R;McFarlane D;Dougan G;Pybus OG;Angelis D;Maxwell PH;Peacock SJ;Weekes MP;Illingworth C;Harrison EM;Matheson NJ;Goodfellow IG
了解SARS-CoV-2在高等教育环境中的传播对于限制学生之间的传播和进入高危人群非常重要。在这项研究中，我们对2020年10月5日至12月6日从剑桥大学分离的482株SARS-CoV-2进行了测序。我们对来自周围社区的972个分离株进行了详细的系统发育比较，并辅之以流行病学和接触者追踪数据，以确定传播动力学。我们观察到进入大学的病毒式传播有限；大多数学生病例与单一基因簇有关，可能是在大学外的社交聚会之后。我们确定了与学生住宿和课程相关的相当大的向前传播；通过采取当地感染控制措施并在全国封锁之后，这一情况得到了有效控制。传播集群在很大程度上是在大学或社区内隔离的。我们的研究强调了SARS-CoV-2传播的关键决定因素以及在高等教育环境中的有效干预措施，这将为大流行期间的公共卫生政策提供信息。在这项研究中，Aggarwal和他的同事对来自剑桥大学无症状学生筛查和对学生和教职员工进行症状测试的SARS-CoV-2分离株进行了前瞻性测序。他们确定了在大学内部传播并向更广泛的社区传播的重要因素。
Understanding SARS-CoV-2 transmission in higher education settings is important to limit spread between students, and into at-risk populations. In this study, we sequenced 482 SARS-CoV-2 isolates from the University of Cambridge from 5 October to 6 December 2020. We perform a detailed phylogenetic comparison with 972 isolates from the surrounding community, complemented with epidemiological and contact tracing data, to determine transmission dynamics. We observe limited viral introductions into the university; the majority of student cases were linked to a single genetic cluster, likely following social gatherings at a venue outside the university. We identify considerable onward transmission associated with student accommodation and courses; this was effectively contained using local infection control measures and following a national lockdown. Transmission clusters were largely segregated within the university or the community. Our study highlights key determinants of SARS-CoV-2 transmission and effective interventions in a higher education setting that will inform public health policy during pandemics. In this study, Aggarwal and colleagues perform prospective sequencing of SARS-CoV-2 isolates derived from asymptomatic student screening and symptomatic testing of students and staff at the University of Cambridge. They identify important factors that contributed to within university transmission and onward spread into the wider community.
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DOI：
10.1093/cid/ciab343
发表时间：
2021-07-15
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
Moreno GK;Braun KM;Pray IW;Segaloff HE;Lim A;Poulsen K;Meiman J;Borcher J;Westergaard RP;Moll MK;Friedrich TC;O'Connor DH
通讯作者：
O'Connor DH
影响因子：
3.9
作者：
Connor TR;Loman NJ;Thompson S;Smith A;Southgate J;Poplawski R;Bull MJ;Richardson E;Ismail M;Thompson SE;Kitchen C;Guest M;Bakke M;Sheppard SK;Pallen MJ
通讯作者：
Pallen MJ
影响因子：
10.7
作者：
Minh BQ;Nguyen MA;von Haeseler A
通讯作者：
von Haeseler A
DOI：
10.3390/ijerph17113984
发表时间：
2020-06-01
影响因子：
--
作者：
Choi, Hemin;Cho, Wonhyuk;Hur, Joon-Young
通讯作者：
Hur, Joon-Young
影响因子：
3.9
作者：
Argimón S;Abudahab K;Goater RJE;Fedosejev A;Bhai J;Glasner C;Feil EJ;Holden MTG;Yeats CA;Grundmann H;Spratt BG;Aanensen DM
通讯作者：
Aanensen DM