Accounting for sex-related differences in the estimation of breath alcohol concentrations using transdermal alcohol monitoring
Accounting for sex-related differences in the estimation of breath alcohol concentrations using transdermal alcohol monitoring
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DOI：
10.1007/s00213-014-3644-9
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发表时间：
2015-01-01
影响因子：
3.4
通讯作者：
Dougherty, Donald M.
中科院分区：
文献类型：
--
作者：
Hill-Kapturczak, Nathalie;Roache, John D.;Dougherty, Donald M.
此前，我们报告了从经皮酒精浓度（TAC）估计呼气酒精峰值浓度（BrAC）的方法。在控制饮酒量以在两种性别中产生相似的BrAC水平的条件下，本研究描述了BrAC和TAC之间关系的差异作为性别的函数，并开发了一个模型来预测BrAC峰值，该模型解释了已知的BrAC峰值的性别差异。在不同的日子里喝不同数量的啤酒。男性（n = 11）和女性（n = 10）在2小时内以相同的速度消耗了1，2，3，4和5瓶啤酒。性别和性别相关的变量被认为是纳入一个多层次的模型，以开发一个方程来估计峰值BrAC水平从TAC.While峰值BrAC水平显着高于男性的女性，性别差异并不显着在观察到的TAC水平。这种缺乏对应性的证据是显着的性别差异之间的关系峰值TAC和峰值BrAC。估计BrAC峰值的最佳模型通过包括TAC峰值、至TAC峰值时间和性别来解释性别相关差异。使用先前收集的数据进一步验证了该模型。男性和女性之间的TAC峰值和实际BrAC峰值之间的关系不同，这些差异可以在统计模型中解释，以更好地估计BrAC峰值。需要进一步的研究，以扩大这些估计的峰值BrAC的门诊环境中自然饮酒发生。
Previously, we reported methods to estimate peak breath alcohol concentrations (BrAC) from transdermal alcohol concentrations (TAC) under conditions where alcohol consumption was controlled to produce similar BrAC levels in both sexes.This study characterized differences in the relationship between BrAC and TAC as a function of sex and developed a model to predict peak BrAC that accounts for known sex differences in peak BrAC.TAC and BrAC were monitored during the consumption of a varying number of beers on different days. Both men (n = 11) and women (n = 10) consumed one, two, three, four, and five beers at the same rate in a 2-h period. Sex and sex-related variables were considered for inclusion in a multilevel model to develop an equation to estimate peak BrAC levels from TAC.While peak BrAC levels were significantly higher in women than men, sex differences were not significant in observed TAC levels. This lack of correspondence was evidenced by significant sex differences in the relationship between peak TAC and peak BrAC. The best model to estimate peak BrAC accounted for sex-related differences by including peak TAC, time-to-peak TAC, and sex. This model was further validated using previously collected data.The relationship between peak TAC and actual peak BrAC differs between men and women, and these differences can be accounted for in a statistical model to better estimate peak BrAC. Further studies are required to extend these estimates of peak BrAC to the outpatient environment where naturalistic drinking occurs.