Development of a tissue-equivalent MRI phantom using carrageenan gel
Development of a tissue-equivalent MRI phantom using carrageenan gel
复制标题
DOI：
10.1002/mrm.10619
复制
发表时间：
2003-11-01
影响因子：
3.3
通讯作者：
Hiraki, Y
中科院分区：
文献类型：
--
作者：
Yoshimura, K;Kato, H;Hiraki, Y
研制了一种基于卡拉胶凝胶的新型组织等效磁共振体模。卡拉胶凝胶是一种理想的固化剂，用于制作各种形状的大型、坚固的幻影。添加GdCl3作为T-1修饰剂和琼脂糖作为T-2修饰剂。使用1.5T临床磁共振成像设备估计了大量样品的松弛时间。在卡拉胶浓度固定为3%的情况下，当GdCl3浓度从0-140mol/kg变化，琼脂糖浓度从0-1.6%变化时，所开发的模型的T-1值为202-1904ms，T-2值为38-423ms。测量的松弛时间范围涵盖了所有类型的人体组织。建立了将松弛时间与改性剂浓度联系起来的经验公式，使达到所需松弛时间所需的改性剂浓度能够准确而容易地计算出来。这使得能够创建具有T-1和T-2值的任意组合并且能够保持其形状的体模。《医学评论》50：1011-1017,2003。(C)2003年Wiley-Liss，Inc.
A new tissue-equivalent MRI phantom based on carrageenan gel was developed. Carrageenan gel is an ideal solidifying agent for making large, strong phantoms in a wide variety of shapes. GdCl3 was added as a T-1 modifier and agarose as a T-2 modifier. The relaxation times of a very large number of samples were estimated using 1.5-T clinical MRI equipment. The developed phantom was found to have a T-1 value of 202-1904 ms and a T-2 value of 38-423 ms when the GdCl3 concentration was varied from 0-140 mumol/kg and the agarose concentration was varied from 0-1.6% in a carrageenan concentration that was fixed at 3%. The range of measured relaxation times covered those of all types of human tissue. Empirical formulas linking the relaxation time with the concentration of the modifier were established to enable the accurate and easy calculation of the modifier concentration needed to achieve the required relaxation times. This enables the creation of a phantom having an arbitrary combination of T-1 and T-2 values and which is capable of retaining its shape. Magn Reson Med 50:1011-1017, 2003. (C) 2003 Wiley-Liss, Inc.