Use of Cultured Cells to Study Alcohol Metabolism
Use of Cultured Cells to Study Alcohol Metabolism
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使用培养细胞研究酒精代谢
DOI:
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发表时间:
2006
期刊:
影响因子:
--
通讯作者:
D. Clemens
中科院分区:
文献类型:
--
作者:
D. Clemens
The use of cells grown in the laboratory (i.e., cultured cells) in alcohol research has many advantages. Among these are the ability to investigate individual metabolic pathways, the ability to precisely control exposure to ethanol and its metabolites in the absence of confounding variables, and the uniformity of genetically identical (i.e., clonal) cell lines. Additionally, because of the cost and relative ease of culturing large quantities of cells, many more experimental replicas may be performed to confirm findings. As described in this article, the use of cultured cells has contributed greatly to the understanding of the mechanisms by which alcohol metabolism affects cells and ultimately results in alcoholic liver disease.
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影响因子:
3.6
作者:
Chen, Q;Cederbaum, AI
通讯作者:
Cederbaum, AI
影响因子:
4
作者:
Shanks,MR;Cassio,D;Lecoq,O;Hubbard,AL
通讯作者:
Hubbard,AL
DOI:
10.1152/ajpgi.00442.2002
发表时间:
2003-09-01
影响因子:
4.5
作者:
Pastorino, JG;Shulga, N;Hoek, JB
通讯作者:
Hoek, JB
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4.8
作者:
Galli, A;Pinaire, J;Crabb, DW
通讯作者:
Crabb, DW
影响因子:
3.8
作者:
J. Huan;J. Streicher;L. Bleyle;D. Koop
通讯作者:
J. Huan;J. Streicher;L. Bleyle;D. Koop