Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles.
Regulation of Neurogenesis by Neurotrophins during Adulthood: Expected and Unexpected Roles.
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在成年期神经营养蛋白对神经发生的调节：预期和意外的作用。
DOI：
10.3389/fnins.2016.00026
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发表时间：
2016
影响因子：
4.3
通讯作者：
Mira H
中科院分区：
文献类型：
--
作者：
Vilar M;Mira H
前外侧脑室的室下区（SVZ）和海马齿状回的颗粒下区（SGZ）是成年哺乳动物大脑的两个主要区域，其中神经发生在整个生命过程中得以维持。由于成人神经发生的改变似乎是不同神经退行性疾病的共同标志，因此了解控制成人神经发生的分子机制是积极研究的焦点。神经营养因子是一类分子，在神经元发育过程中的存活和分化以及成人神经可塑性的控制中发挥着关键作用。几种神经营养蛋白和神经营养蛋白受体在不同水平上参与成人神经发生的调节。在这里，我们回顾了目前对神经营养蛋白调节 SVZ 和 SGZ 成人神经发生的理解。我们编译的数据支持神经营养素/神经营养素受体在不同情况下的各种作用，包括预期和意外的功能。
The subventricular zone (SVZ) of the anterolateral ventricle and the subgranular zone (SGZ) of the hippocampal dentate gyrus are the two main regions of the adult mammalian brain in which neurogenesis is maintained throughout life. Because alterations in adult neurogenesis appear to be a common hallmark of different neurodegenerative diseases, understanding the molecular mechanisms controlling adult neurogenesis is a focus of active research. Neurotrophic factors are a family of molecules that play critical roles in the survival and differentiation of neurons during development and in the control of neural plasticity in the adult. Several neurotrophins and neurotrophin receptors have been implicated in the regulation of adult neurogenesis at different levels. Here, we review the current understanding of neurotrophin modulation of adult neurogenesis in both the SVZ and SGZ. We compile data supporting a variety of roles for neurotrophins/neurotrophin receptors in different scenarios, including both expected and unexpected functions.