Cardiac developmental biology: from flies to humans.
Cardiac developmental biology: from flies to humans.
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DOI：
10.2170/jjphysiol.m94
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发表时间：
2005-10
期刊：
影响因子：
--
通讯作者：
I. Shiojima;I. Komuro
中科院分区：
文献类型：
--
作者：
I. Shiojima;I. Komuro
心脏是胚胎发生过程中第一个形成的器官，心脏的形成对于随后的胚胎发育至关重要。自从 20 世纪 90 年代初鉴定出心脏限制性转录因子 Csx/Nkx-2.5 以来，人们对从果蝇到人类的各种物种的心脏发育进行了广泛的研究。对控制心脏发生多个步骤的调控途径进行分子解剖不仅将增进我们对心脏发育和先天性心脏病的理解，而且还将为心脏病的新治疗策略提供重要线索。
The heart is the first organ to form during embryogenesis, and heart formation is essential for subsequent embryonic development. Since the identification of a cardiac-restricted transcription factor Csx/Nkx-2.5 in the early 1990s, extensive studies on cardiac development have been done in various species ranging from flies to humans. Molecular dissection of regulatory pathways that control multiple steps of cardiogenesis will not only advance our understanding of cardiac development and congenital heart diseases, but will also provide an important clue to novel therapeutic strategies for heart diseases.