Left and Right Ventricular Pump Function and Consequences of Having Two Pumps in One Heart: A Study on the Isolated Cat Heart
Left and Right Ventricular Pump Function and Consequences of Having Two Pumps in One Heart: A Study on the Isolated Cat Heart
复制标题
左心室和右心室泵功能以及一颗心脏有两个泵的后果：离体猫心脏的研究
作者：
G. Elzinga;H. Piene;J. D. de Jong
本文比较了猫离体心脏射血实验中左右心室自然串联排列被破坏后的泵功能。通过改变动脉负荷获得的平均心室压力和输出之间的关系，即所谓的泵功能图，以及在各种负荷水平下发现的平均外部功率输出，被用作比较的基础。右心室产生的压力和流量通过负荷动脉系统的阻力和顺应性的改变而改变的方式，在性质上类似于先前对心脏左侧的研究中发现的情况，尽管存在结构差异。右心室泵功能曲线与左心室曲线在平均压力轴的绝对标度上不同，但如果适当调整标度，两条曲线看起来相似。两个心室似乎与其各自动脉系统的输入阻抗匹配，因为它们在正常负载条件下都产生最大外部功率。右心室泵功能取决于左心室收缩模式。心脏左侧等容搏动的存在增强了右心室泵功能。这与右心室收缩模式对心脏左侧的泵功能的非常小的影响形成对比。CircRes 46：564-574，1980
We compared pump function of left and right ventricles in isolated ejecting cat hearts in which the natural series arrangement between the two sides of the heart was broken. The relationship between mean ventricular pressure and output obtained by varying the arterial load, the so-called pump function graph, and the mean external power output found at the various load levels, was taken as the basis for the comparison. The way in which pressures and flow generated by the right ventricle are changed by alterations in resistance and compliance of the loading arterial system, is qualitatively similar to what has been found in a previous study for the left side of the heart, in spite of the structural differences. The right ventricular pump function curve differs from the left ventricular curve in the absolute scale for the mean pressure axis, but if the scale is adjusted appropriately, the two curves look alike. Both ventricles appear matched to the input impedances of their respective arterial systems because both of them generate the maximum external power under the normal loading conditions. Right ventricular pump function is dependent on the left ventricular contraction mode. The presence of an isovolumic beat on the left side of the heart enhances right ventricular pump function. This is in contrast to the very small effect of the right ventricular contraction pattern on the pump function of the left side of the heart. Circ Res 46: 564-574, 1980