THE PROXIMO-DISTAL SPREAD OF AXONAL DEGENERATION IN THE DORSAL COLUMNS OF THE RAT
THE PROXIMO-DISTAL SPREAD OF AXONAL DEGENERATION IN THE DORSAL COLUMNS OF THE RAT
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DOI：
10.1007/bf01181641
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发表时间：
1994-11-01
期刊：
影响因子：
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通讯作者：
GRIFFIN, JW
中科院分区：
文献类型：
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作者：
GEORGE, R;GRIFFIN, JW
华勒变性的关键事件是轴突的破坏。建立轴突变性的病理生理学对于理解其他类型神经变性的发病机制具有重要意义。病理生理学的一个关键方面是横断后传播的时空模式，这个问题仍然存在争议。我们研究了 L(4)L(5)L(6) 背神经根切开术后大鼠背柱轴突变性的进展。轴突变性以近远端方式进行，从横断部位附近开始，以约 3 mm h(-1) 的净速率向上扩散到背侧柱。此外，薄核中的前终末轴突早期变性。这种模式表明，通过持续的顺行运输从远端残端“清除”轴突运输的材料可能是横断后轴突断裂的基础。
The pivotal event in Wallerian degeneration is the breakdown of the axon. Establishing the pathophysiology of axonal degeneration has implications for the understanding of the pathogenesis of other types of nerve degenerations. A key aspect of the pathophysiology is the spatiotemporal pattern of spread after transection, an issue that has remained controversial. We have studied the progression of axonal degeneration in the dorsal columns of the rat following L(4)L(5)L(6) dorsal radiculotomy. Axonal degeneration proceeds in a proximo-distal fashion, beginning near the site of transection and spreading up the dorsal columns at a net rate of about 3 mm h(-1). In addition, there was early degeneration of the preterminal axons in the gracile nuclei. This pattern suggests that the 'clearing' of axonally transported materials from the distal stump by continued anterograde transport may underlie axonal breakdown after transection.