Milk accumulation triggers apoptosis of mammary epithelial cells.
Milk accumulation triggers apoptosis of mammary epithelial cells.
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乳汁积累会引发乳腺上皮细胞的凋亡。
DOI：
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发表时间：
1997
影响因子：
6.6
通讯作者：
R. Jaggi
中科院分区：
文献类型：
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作者：
A. Marti;Zhiwei Feng;Altermatt Hj;R. Jaggi
连续产奶是催乳激素复杂相互作用的结果，它取决于哺乳期间的吮吸刺激。退化与腺体大量充盈乳汁有关，随后是分泌上皮细胞凋亡和腺体重构。哺乳期单个腺体的封闭足以诱导最初的充血和随后的肺泡结构塌陷以及大量上皮细胞死亡，而同一动物的其他腺体在形态和功能上仍处于哺乳状态。许多退化的标志物，如硫酸化糖蛋白-2，蛋白激酶A，转录因子AP-1和最显着的基质溶解素在密封的腺体中诱导。这些研究结果表明，细胞死亡途径是独立的催乳激素的全身水平，但它是由乳汁中的催乳素诱导因子的积累，在小叶肺泡结构或由分泌性上皮细胞的物理变形所产生的充血触发。
Continuous milk production is a consequence of a complex interplay of lactogenic hormones and it depends on the suckling stimulus during lactation. Involution is associated with a massive engorgement of the gland with milk followed by apoptosis of secretory epithelial cells and a restructing of the gland. Sealing of a single gland during lactation is sufficient to induce an initial engorgement and a subsequent collapse of alveolar structures and massive epithelial cell death while the other glands of the same animal remain morphologically and functionally in a lactating state. Many markers of involution such as sulfated glycoprotein-2, protein kinase A, transcription factor AP-1 and most notably stromelysin are induced in sealed glands. These findings suggest a cell death pathway which is independent of the systemic levels of lactogenic hormones but which is triggered by an accumulation of apoptosis-inducing factors in the milk, in the lobulo-alveolar structures or by a physical distortion of secretory epithelial cells generated by the engorgement.