What happens when growth cones meet neurites: attraction or repulsion?
What happens when growth cones meet neurites: attraction or repulsion?
复制标题
当生长锥遇到神经突时会发生什么：吸引还是排斥？
DOI：
10.1016/0166-2236(87)90003-8
复制
发表时间：
1987
影响因子：
15.9
通讯作者：
Paul C. Letourneau
中科院分区：
文献类型：
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作者：
Paul C. Letourneau
没有惊厥，寿命更长，尽管这些动物中MBP mRNA的丰度估计分别为正常的13.5%和12.5%，并且髓鞘超微结构没有明显差异。这些优雅的研究提供了正式的遗传学证据，证明颤抖小鼠的表型是MBP基因缺失的结果。此外，这项工作表明髓鞘形成不是一个全有或全无的事件，而是髓鞘形成的程度取决于其蛋白质组分中至少一种的表达水平。不同髓鞘形成程度的小鼠品系的生产将是髓鞘形成和髓鞘形成障碍的生理后果的研究的重要资源。人们还认为，类似的研究将进行t！H，Ii ~ ma，因为它们的分子缺陷被定义。例如，突变小鼠jimpy由于蛋白脂质蛋白（PLP）基因转录物的异常剪接而显示出严重的CNS髓鞘形成不足19 ′ 2。Klaus-Armin Nave在本通讯员的实验室中最近已经证明，该缺陷是由PLP基因21的共有剪接位点中的单个碱基变化引起的。我们热切地期待着对其他髓鞘形成障碍突变体进行类似的分子遗传学分析，以增加我们对髓鞘形成重要过程的理解。
not have convulsions, and live longer, although the abundances of MBP mRNA in these animals are estimated to be 13.5% and 12.5% of normal, respectively, and there are no apparent differences in the myelin ultrastructure. These elegant studies provide formal genetic proof that the phenotype of the shiverer mouse is the consequence of a deletion in the gene for MBP. In addition, this work indicates that myelination is not an all-or-none event but that the degree of myelination is dependent on the levels of expression of at least one of its protein components. The production of lines of mice with varying degrees of myelination will be an important resource for the study of myelination and the physiological consequences of dysmyelination. One also assumes that similar studies will be carried out t! H, i i~ ma for other dysmyelinating mutants as their molecular defects are defined. The mutant mouse jimpy, for example, displays severe CNS hypomyelination as a result of aberrant splicing of proteolipid protein (PLP) gene transcripts 19'2. Klaus-Armin Nave in this correspondent's laboratory has recently demonstrated that the defect results from a single base change in a consensus splice site of the PLP gene 21. We eagerly await a similar molecular genetic analysis of other dysmyelinating mutants to increase our understanding of the vital process of myelination.