Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.
Interleukin-28B gene polymorphisms do not influence the susceptibility to HIV-infection or CD4 cell decline.
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Interleukin-28B 基因多态性不会影响 HIV 感染或 CD4 细胞下降的易感性。
DOI：
10.1097/qad.0b013e328341b84e
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Benito,JoseM
中科院分区：
文献类型：
--
作者：
Rallon,NormaI;Restrepo,Clara;Naggie,Susanna;Lopez,Mariola;DelRomero,Jorge;Goldstein,David;McHutchison,John;Soriano,Vincent;Benito,JoseM
The critical role of interleukin-28B (IL28B)/interferon-λ3 (IFN-λ3) polymorphisms on the susceptibility to hepatitis C virus infection and the response to peginterferon–ribavirin therapy has encouraged exploration of similar effects on other viruses. Given that IFN-λ mediates anti-HIV-1 activity, the protective role of IL28B polymorphisms was examined in 29 seronegative individuals at risk for HIV-infection and in 68 HIV-positive carriers with and without rapid progression of immunodeficiency. No protective role of IL28B polymorphism was found examining both HIV-disease progression and HIV-protection.
