INFLUENCE OF SKIN CLEANSING PREPARATION ACIDITY ON SKIN SURFACE-PROPERTIES
INFLUENCE OF SKIN CLEANSING PREPARATION ACIDITY ON SKIN SURFACE-PROPERTIES
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DOI：
10.1111/j.1467-2494.1991.tb00552.x
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发表时间：
1991-04-01
影响因子：
2.3
通讯作者：
BRAUNFALCO, O
中科院分区：
文献类型：
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作者：
KORTING, HC;MEGELE, M;BRAUNFALCO, O
进行两项为期8周的长期试验，比较定期使用pH 5.5和pH 8.5以及pH 5.5和pH 7.0的皮肤清洁制剂对正常人额头和前臂皮肤表面pH、粗糙度和经皮失水（TEWL）的影响。这两项试验都基于交叉设计：五名健康志愿者开始使用pH为5.5的制剂，四周后切换到另一种制剂，另外五名志愿者以相反的顺序使用制剂。与使用pH 8.5或pH 7.0制剂的个体相比，每次检查时使用pH 5.5制剂的个体皮肤表面pH值明显较低，但在皮肤粗糙度和TEWL方面没有这种差异。因此，在测试的pH值范围内，清洁制剂的皮肤刺激性似乎与它的pH值无关。
Two long-term trials were conducted each over eight weeks to compare the effect of the regular application of skin cleansing preparations of pH 5.5 and pH 8.5 and pH 5.5 and pH 7.0 respectively on the surface pH, roughness and transepidermal water loss (TEWL) of normal human forehead and forearm skin. Both trials were based on a cross-over design: five healthy volunteers started with a pH 5.5 preparation and switched to the other after four weeks, five additional volunteers used the preparations in the opposite order. While the skin surface pH was markedly lower in those individuals using the pH 5.5 preparation at each examination, as compared to those using the pH 8.5 or pH 7.0 preparation, no such difference could be established with respect to skin roughness and TEWL. Hence the skin irritancy of a cleansing preparation does not seem to be linked to its pH within the pH ranges tested.