CD14 IS A PATTERN-RECOGNITION RECEPTOR
CD14 IS A PATTERN-RECOGNITION RECEPTOR
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DOI：
10.1016/1074-7613(94)90093-0
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发表时间：
1994-09-01
期刊：
影响因子：
32.4
通讯作者：
ULEVITCH, RJ
中科院分区：
文献类型：
--
作者：
PUGIN, J;HEUMANN, D;ULEVITCH, RJ
感染性休克是由多种细菌病原体引起的严重的人类疾病。细菌包膜成分的识别是哺乳动物细胞用于启动导致细菌杀死的反应的一种机制，或者不幸的是，也引起致命的败血性休克的反应。在这里，我们表明，CD 14起着关键作用，在启动细胞活化的一组细菌包膜组件从革兰氏阴性和革兰氏阳性微生物，以及分枝杆菌。我们提出，CD 14是一种受体，用于哺乳动物细胞识别和信号响应的细菌成分的多样化阵列。这一发现定义了先天微生物免疫的分子基础;这些发现隐含着治疗的新可能性。
Septic shock caused by a diverse group of bacterial pathogens is a serious human disease. Recognition of bacterial envelope constituents is one mechanism used by mammalian cells to initiate responses leading to bacterial killing or, unfortunately, responses that also cause fatal septic shock. Here we show that CD14 plays a key role in initiating cell activation by a group of bacterial envelope components from Gram-negative and Gram-positive microorganisms, as well as mycobacteria. We propose that CD14 is a receptor used by mammalian cells to recognize and signal responses to a diverse array of bacterial constituents. This finding defines the molecular basis for innate microbial immunity; implicit in these findings are new possibilities for therapeutics.