Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice
Evaluation of Resveratrol, Green Tea Extract, Curcumin, Oxaloacetic Acid, and Medium-Chain Triglyceride Oil on Life Span of Genetically Heterogeneous Mice
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DOI：
10.1093/gerona/gls070
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发表时间：
2013-01-01
影响因子：
5.1
通讯作者：
Harrison, David E.
中科院分区：
文献类型：
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作者：
Strong, Randy;Miller, Richard A.;Harrison, David E.
国家衰老干预测试计划研究所（ITP）的建立是为了评估那些被认为可以延长基因异质小鼠寿命和/或健康寿命的药物。每种化合物在三个试验点平行测试。ITP的目标是公布所有结果，无论是正面的还是负面的。我们在这里报告了终身治疗小鼠的结果，从4个月大开始，分别使用五种药物，即绿茶提取物（GTE），姜黄素。草酰乙酸、中链甘油三酯油和白藜芦醇对遗传异质性小鼠寿命的影响。每种药物在4个月大时开始使用。通过对数秩检验，在测试的浓度下，这五种药物对雄性或雌性小鼠的寿命都没有统计学上显著的影响，尽管一项二次分析表明，GTE可能只会降低雌性小鼠中年死亡的风险。
The National Institute on Aging Interventions Testing Program (ITP) was established to evaluate agents that are hypothesized to increase life span and/or health span in genetically heterogeneous mice. Each compound is tested in parallel at three test sites. It is the goal of the ITP to publish all results, negative or positive. We report here on the results of lifelong treatment of mice, beginning at 4 months of age, with each of five agents, that is, green tea extract (GTE), curcumin. oxaloacetic acid, medium-chain triglyceride oil, and resveratrol, on the life span of genetically heterogeneous mice. Each agent was administered beginning at 4 months of age. None of these five agents had a statistically significant effect on life span of male or female mice, by log-rank test, at the concentrations tested, although a secondary analysis suggested that GTE might diminish the risk of midlife deaths in females only.