UBIQUITIN, PROTEASOMES, AND THE REGULATION OF INTRACELLULAR PROTEIN-DEGRADATION
UBIQUITIN, PROTEASOMES, AND THE REGULATION OF INTRACELLULAR PROTEIN-DEGRADATION
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DOI：
10.1016/0955-0674(95)80031-x
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发表时间：
1995-04-01
影响因子：
7.5
通讯作者：
HOCHSTRASSER, M
中科院分区：
文献类型：
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作者：
HOCHSTRASSER, M
通过泛素/蛋白酶体依赖性途径快速降解特定蛋白质是许多细胞调节机制的组成部分。最近的研究表明，蛋白质泛素化和去泛素化都是由大家族的酶介导的，蛋白质水解可以通过蛋白酶体本身的改变来调节。泛素系统的复杂性反映在它调节的广泛过程中;这些过程包括细胞周期进程中的关键步骤，I类MHC分子呈递外源蛋白的加工以及细胞增殖的控制。
Rapid degradation of specific proteins by ubiquitin/proteasome-dependent pathways is a component of many cellular regulatory mechanisms. Recent work has shown that protein ubiquitination and deubiquitination are both mediated by large families of enzymes and that proteolysis can be modulated by alterations of the proteasome itself. The complexity of the ubiquitin system is reflected in the broad range of processes it regulates; these include key steps in cell cycle progression, processing of foreign proteins for presentation by class I MHC molecules, and the control of cell proliferation.