Frontal-subcortical neuronal circuits and clinical neuropsychiatry - An update
Frontal-subcortical neuronal circuits and clinical neuropsychiatry - An update
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DOI：
10.1016/s0022-3999(02)00428-2
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发表时间：
2002-08-01
影响因子：
4.7
通讯作者：
Cummings, JL
中科院分区：
文献类型：
--
作者：
Tekin, S;Cummings, JL
额叶皮层下回路形成了介导人类运动活动和行为的主要网络，五个平行的额叶皮层下回路将额叶皮层的特定区域与纹状体、基底神经节和丘脑联系起来。这些额叶-皮层下回路起源于额叶皮层的辅助运动区、额叶眼区、背外侧前额叶区、外侧眶额区和前扣带回部分。开放的传入和传出连接到额叶皮层下回路调解大脑功能相似区域之间的协调。特定的化学结构和多种神经递质相互作用调节每个回路的功能活动。背外侧前额叶回路损伤导致执行功能障碍，眶额回路损伤导致以去抑制为特征的人格改变，前扣带回回路损伤表现为冷漠。神经精神障碍包括抑郁症、强迫症、精神分裂症和物质滥用的神经生物学相关性暗示了额叶皮层下回路的参与。(C)2002年爱思唯尔科技有限公司All rights reserved.
Frontal-subcortical circuits form the principal network, which mediate motor activity and behavior in humans, Five parallel frontal-subcortical circuits link the specific areas of the frontal cortex to the striatum, basal ganglia and thalamus. These Frontal-subcortical circuits originate from the supplementary motor area, frontal eye Field, dorsolateral prefrontal region, lateral orbitofrontal region and anterior cingulate portion of the frontal cortex. The open afferent and efferent connections to the frontal-subcortical circuits mediate coordination between functionally similar areas of the brain. Specific chemoarchitecture and multiple neurotransmitter interactions modulate the functional activity of each circuit. Dorsolateral prefrontal circuit lesions cause executive dysfunction, orbitofrontal circuit lesions lead to personality changes characterized by disinhibition and anterior cingulate circuit lesions present with apathy. The neurobiological correlates of neuropsychiatric disorders including depression, obsessive-compulsive disorder, schizophrenia and substance abuse, imply involvement of frontal-subcortical circuits. (C) 2002 Elsevier Science Inc. All rights reserved.