The Cardiovascular and Metabolic Effects of Chronic Hypoxia in Animal Models: A Mini-Review.
The Cardiovascular and Metabolic Effects of Chronic Hypoxia in Animal Models: A Mini-Review.
复制标题
DOI：
10.3389/fphys.2022.873522
复制
发表时间：
2022
影响因子：
4
通讯作者：
Sanchez-Azofra, Ana
中科院分区：
文献类型：
--
作者：
Barnes, Laura A.;Mesarwi, Omar A.;Sanchez-Azofra, Ana
动物模型有助于理解低氧的各种生理效应。这些模型试图以不同的方式重述人类疾病的低氧血症。在这篇简短的综述中，我们考虑了各种动物模型，这些模型已经被用来了解慢性低氧对肺和全身血压、糖脂代谢、动脉粥样硬化和中风的影响。慢性持续性缺氧(CSH)是一种慢性肺病或心脏病的模型，在这种模型中，低氧血症可能是长期和持续的，或者是在高海拔地区，在这种情况下，有效空气中的氧气浓度很低，可以可靠地诱导啮齿类动物的肺动脉高压，并似乎对糖代谢具有保护作用。慢性间歇性低氧(CIH)长期以来一直被用作阻塞性睡眠呼吸暂停(OSA)的模型，在阻塞性睡眠呼吸暂停(OSA)中，反复的呼吸道阻塞会导致夜间氧合血红蛋白饱和度的间歇性降低。CIH首先被证明可以增加全身血压，但也与其他适应不良的生理变化有关，包括葡萄糖调节失调、动脉粥样硬化、非酒精性脂肪性肝病的进展和内皮功能障碍。然而，CIH的模型通常是为了模拟严重的人类OSA而实施的，相对较少关注较温和的低氧方案。在这里，我们从概念上讨论CSH和CIH，这些刺激的影响，以及现有数据的局限性。
Animal models are useful to understand the myriad physiological effects of hypoxia. Such models attempt to recapitulate the hypoxemia of human disease in various ways. In this mini-review, we consider the various animal models which have been deployed to understand the effects of chronic hypoxia on pulmonary and systemic blood pressure, glucose and lipid metabolism, atherosclerosis, and stroke. Chronic sustained hypoxia (CSH)—a model of chronic lung or heart diseases in which hypoxemia may be longstanding and persistent, or of high altitude, in which effective atmospheric oxygen concentration is low—reliably induces pulmonary hypertension in rodents, and appears to have protective effects on glucose metabolism. Chronic intermittent hypoxia (CIH) has long been used as a model of obstructive sleep apnea (OSA), in which recurrent airway occlusion results in intermittent reductions in oxyhemoglobin saturations throughout the night. CIH was first shown to increase systemic blood pressure, but has also been associated with other maladaptive physiological changes, including glucose dysregulation, atherosclerosis, progression of nonalcoholic fatty liver disease, and endothelial dysfunction. However, models of CIH have generally been implemented so as to mimic severe human OSA, with comparatively less focus on milder hypoxic regimens. Here we discuss CSH and CIH conceptually, the effects of these stimuli, and limitations of the available data.
登录
查看更多内容
影响因子：
2.7
作者：
Braga, Valdir A.;Soriano, Renato N.;Machado, Benedito H.
通讯作者：
Machado, Benedito H.
影响因子：
76.2
作者：
Benjafield, Adam V.;Ayas, Najib T.;Malhotra, Atul
通讯作者：
Malhotra, Atul
影响因子：
3.3
作者：
BENDER, PR;GROVES, BM;REEVES, JT
通讯作者：
REEVES, JT
DOI：
10.1164/rccm.201209-1688oc
发表时间：
2013-07-15
影响因子：
24.7
作者：
Drager, Luciano F.;Yao, Qiaoling;Polotsky, Vsevolod Y.
通讯作者：
Polotsky, Vsevolod Y.
影响因子：
3.3
作者：
Fagan, KA
通讯作者：
Fagan, KA