CYCLES AND SEPARATIONS - THE HISTOTOPOGRAPHY OF THE URINARY CONCENTRATING PROCESS
CYCLES AND SEPARATIONS - THE HISTOTOPOGRAPHY OF THE URINARY CONCENTRATING PROCESS
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DOI：
10.1038/ki.1987.33
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发表时间：
1987-02-01
影响因子：
19.6
通讯作者：
KRIZ, W
中科院分区：
文献类型：
--
作者：
LEMLEY, KV;KRIZ, W
在本文中，我们提出了一些肾髓质的组织地形图特征，即髓质各种结构元素的相对空间构型，这在尿液浓缩过程中可能是重要的。自提出“增殖原理”以来的几年里，我们对哺乳动物肾脏的结构和功能特征的认识已经有了相当大的改进。然而，我们目前对肾髓质组织地形图的全面了解并没有普遍反映在尿液浓缩机制的模型中。通过介绍肾髓质组织结构造影术的一些可能的功能后果，我们希望刺激在未来的尿液浓度模型中更全面地结合肾脏结构的这些方面。我们的讨论几乎完全局限在老鼠身上，因为这种物种似乎最容易用一种综合的方法来理解尿液浓缩过程。
In this article we present a number of features of the histotopography of the renal medulla, that is, the relative spatial configurations of the various structural elements of the medulla, which may be important in the process of urine concentration. In the years since the enunciation of the “multiplication principle” [1], considerable refinement has been achieved in our knowledge of the structural and functional characteristics of the mammalian kidney. The full extent of our present knowledge of the histotopography of the renal medulla has not, however, generally been reflected in models of the urinary concentrating mechanism. By presenting some of the possible functional consequences of renal medullary histotopography, we hope to stimulate a more comprehensive incorporation of these aspects of renal structure in future models of urinary concentration. We have limited our discussion almost exclusively to the rat, since that species seems most amenable to an integrated approach to understanding the urine concentration process.