Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders
Basal activity level in mice predicts the initial and sensitized locomotor response to nicotine only in high responders
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DOI：
10.1016/j.bbr.2014.01.046
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发表时间：
2014-05-01
影响因子：
2.7
通讯作者：
Spanagel, Rainer
中科院分区：
文献类型：
--
作者：
Bernardi, Rick E.;Spanagel, Rainer
并不是所有的人在随意使用毒品后都会上瘾。因此，确定可能导致后续药物反应的因素非常重要。先前的研究已经确定了诸如追求新奇、冲动和焦虑等特征是导致药物依赖的因素。目前的实验研究了C57Bl/6N小鼠的基础运动活动作为随后尼古丁反应的潜在预测因子。我们检查了基础运动活动的差异预测尼古丁急性和敏感反应的能力，以及尼古丁条件强化。中位数分割用于区分小鼠基础运动活动的低反应和高反应。然后，我们测量了这些小鼠对尼古丁（0.5 mg/kg IP）的急性反应，随后测量了条件位置偏好（CPP; 0.5 mg/kg IP）和运动致敏（0.5 mg/kg IP），以确定基础运动是否预测了随后对尼古丁的反应。高而不低的基础活性被发现是尼古丁急性反应和致敏反应的预测因子。有趣的是，只有基础活动较低的小鼠表现出显著的CPP，这表明在初始活动水平的基础上，尼古丁预暴露对条件强化的影响是不同的。基础运动活动可能是对尼古丁反应的后续运动的有效测量，但仅适用于具有高基础活动的动物。然而，基础运动活动低的动物可能更容易受到尼古丁增强特性的影响。(C) 2014 Elsevier B.V.版权所有
Not all humans become addicted to drugs of abuse following casual use. Thus, it is important to identify factors that may contribute to subsequent drug responding. Previous studies have identified characteristics such as novelty-seeking, impulsivity, and anxiety as factors involved in the progression to drug dependence. The current experiment investigated basal locomotor activity in C57Bl/6N mice as a potential predictor of subsequent nicotine responses. We examined the ability of differences in basal locomotor activity to predict the acute and sensitized response to nicotine, as well as nicotine conditioned reinforcement. A median split was used to distinguish between low and high responders with regard to basal locomotor activity in mice. We then measured the acute response to nicotine (0.5 mg/kg IP) in these mice, followed by measures of conditioned place preference (CPP; 0.5 mg/kg IP) and locomotor sensitization (0.5 mg/kg IP), to determine whether basal locomotion is predictive of subsequent responding to nicotine. High, but not low, basal activity was found to be a predictor of both the acute and sensitized response to nicotine. Interestingly, only mice classified as having low basal activity demonstrated a significant CPP, suggesting that pre-exposure to nicotine differentially affects conditioned reinforcement on the basis of initial activity level. Basal locomotor activity may be an efficient measure of subsequent locomotor responding to nicotine, but only in animals classified as having high basal activity. However, animals with low basal locomotor activity may be more susceptible to the reinforcing properties of nicotine. (C) 2014 Elsevier B.V. All rights reserved.