Long‐term follow‐up of a patient with cutaneous vasculitis secondary to mixed cryoglobulinaemia and Hepatitis C virus
Long‐term follow‐up of a patient with cutaneous vasculitis secondary to mixed cryoglobulinaemia and Hepatitis C virus
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混合性冷球蛋白血症和丙型肝炎病毒继发皮肤血管炎患者的长期随访
DOI：
10.1046/j.0307-6938.2001.00942.x
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发表时间：
2002
影响因子：
4.1
通讯作者：
R. Yu
中科院分区：
文献类型：
--
作者：
N. Kapur;P. Tympanidis;C. Colville;R. Yu
总结我们描述了一名混合性冷球蛋白血症和多系统疾病患者21年的临床病程。她的丙型肝炎病毒（HCV）血清学检测结果一直呈阴性，但使用逆转录聚合酶链反应证实了活动性HCV感染（基因型Ia）。在接受干扰素-α和利巴韦林治疗后初步改善后，不幸的是，她发生了严重的中性粒细胞减少症，需要在4周内停用两种药物。 一个月后她去世了。
Summary We describe the clinical course of a patient with mixed cryoglobulinaemia and multisystem disease over a 21‐year period. She consistently tested negative for hepatitis C virus (HCV) serology, but active HCV infection (genotype Ia) was confirmed using reverse transcription–polymerase chain reaction. After initial improvement following treatment with interferon‐α and ribavirin, unfortunately she developed severe neutropenia necessitating discontinuation of both drugs within 4 weeks. She died 1 month later.