Subjective reward value of visual sexual stimuli is coded in human striatum and orbitofrontal cortex
Subjective reward value of visual sexual stimuli is coded in human striatum and orbitofrontal cortex
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DOI：
10.1016/j.bbr.2020.112792
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发表时间：
2020-09-01
影响因子：
2.7
通讯作者：
Stark, Rudolf
中科院分区：
文献类型：
--
作者：
Klein, Sanja;Kruse, Onno;Stark, Rudolf
人类神经成像研究表明，存在一个对奖励进行主观评价的核心网络，包括纹状体和眶额皮质。然而，关于视觉性刺激（VSS）主观奖励值的神经表征以及这些主观评价在相关成瘾行为发展中的作用的研究很少。在这里，我们使用功能磁共振成像（fMRI）研究了VSS的神经反应性如何与个体偏好相关联。在fMRI扫描期间，72名男性观看了不同的VSS电影片段。收集有关效价和性唤起的评分，并将其作为fMRI分析中的参数调制器。受试者还填写了自我报告的问题色情使用症状（PPU）的调查问卷。首先，我们发现伏隔核、尾状核和眶额皮质对VSS片段的神经反应性与受试者各自的VSS评分呈正相关。其次，神经活动和性唤起评分之间的关联强度与自我报告的PPU症状呈正相关。第一个结果表明，根据既定奖励评估区域的个人偏好，对VSS进行了精确的评估。其次，在有更多PPU症状的参与者中，基于偏好的神经分化更强，表明VSS/偏好契合在这些个体中更重要。个体喜好和神经活动之间的高度对应关系可能通过增加刺激显著性信号来促进PPU的发展，从而促进寻求和响应这些首选刺激的动机。
Human neuroimaging research suggests the existence of one core network for the subjective valuation of rewards, including the striatum and orbitofrontal cortex. However, there is little research on the neural representation of subjective reward values of visual sexual stimuli (VSS) and on the role of these subjective valuations in the development of related addictive behaviors. Here, we investigate how neural reactivity to VSS is connected to individual preference using functional magnetic resonance imaging (fMRI). During the fMRI scan, 72 men viewed different VSS film clips. Ratings regarding valence and sexual arousal were collected and used as parametric modulators in the fMRI analysis. Subjects also filled out questionnaires on self-reported symptoms of problematic pornography use (PPU). Firstly, we found that neural reactivity towards VSS clips in the nucleus accumbens, caudate nucleus and orbitofrontal cortex was positively correlated with individual ratings of the respective VSS in all subjects. Second, the strength of the association between neural activity and sexual arousal ratings was positively correlated with self-reported symptoms of PPU. The first result suggests a precise appraisal of VSS according to individual preferences in established reward valuation regions. Secondly, stronger neural differentiation based on preference in participants with more PPU symptoms indicates an increased importance of VSS/preference fit in these individuals. This heightened correspondence between individual liking and neural activity may facilitate PPU development by increased signaling of incentive salience, thus boosting motivation to seek out and respond to these preferred stimuli.