Inverse Association of General Joint Hypermobility With Hand and Knee Osteoarthritis and Serum Cartilage Oligomeric Matrix Protein Levels
Inverse Association of General Joint Hypermobility With Hand and Knee Osteoarthritis and Serum Cartilage Oligomeric Matrix Protein Levels
复制标题
DOI：
10.1002/art.24319
复制
发表时间：
2008-12-01
影响因子：
--
通讯作者：
Kraus, Virginia Byers
中科院分区：
文献类型：
--
作者：
Chen, Hsiang-Cheng;Shah, Svati H.;Kraus, Virginia Byers
客观的。广泛的关节过度活动、较低的血清软骨寡聚基质蛋白（COMP）水平和早发性骨关节炎（OA）是遗传性假性软骨发育不全和多发性骨骺发育不良的表型。然而，很少有研究评估关节过度活动与原发性骨关节炎之间的关联。我们进行本研究来评估这种关联，并检验 COMP 水平与 OA 患者和非 OA 个体的过度活动相关的假设。方法。两个独立的队列可用于分析，CARRIAGE（衰老基因与环境的卡罗莱纳斯地区相互作用）大家族和 GOGO（全身骨关节炎遗传学）同胞队列的子集。在 CARRIAGE 系列中，我们进行了手部和膝盖检查以及过度活动度评估（Beighton 标准），并获得了用于测量 COMP 和透明质酸 (HA) 的血清。 GOGO 队列还提供了有关 COMP 和 HA 水平的数据以及广泛的关节放射学和过度活动数据。结果。 CARRIAGE 家族中过度活动的发生率为 13%，GOGO 队列中为 5%。在 CARRIAGE 家族中，在总队列和非手 OA 亚组中，过度活动与手（尤其是近端指间关节）和膝 OA 患病率显着降低以及平均血清 COMP 水平较低相关。这些结果在没有放射学 OA 的 GOGO 子集中得到了进一步验证，其中过度活动也与平均血清 COMP 水平显着降低相关（根据年龄调整后，P < 0.0001）。在任一队列中，血清 RA 水平与过度活动性没有差异。结论。目前的结果表明，过度活动与手部和膝部 OA 之间存在反比关系，并且过度活动与较低的血清 COMP 水平相关。 COMP 基因的遗传变异可能是良性关节活动过度的某些亚型的原因。
Objective. Extensive joint hypermobility, lower serum cartilage oligomeric matrix protein (COMP) levels, and early-onset osteoarthritis (OA) are phenotypes of inherited pseudoachondroplasia and multiple epiphyseal dysplasia. However, few studies have evaluated the association between articular hypermobility and primary OA. We undertook the present study to evaluate this association and to test the hypothesis that COMP levels are associated with hypermobility in patients with OA and individuals without OA.Methods. Two separate cohorts were available for analysis, the CARRIAGE (CARolinas Region Interaction of Aging Genes and Environment) extended family and a subset of the GOGO (Genetics of Generalized Osteoarthritis) sibpair cohort. In the CARRIAGE family, we performed hand and knee examinations and hypermobility evaluations (Beighton criteria) and obtained sera for measurement of COMP and hyaluronan (HA). Data on COMP and HA levels and extensive joint radiographic and hypermobility data were also available for the GOGO cohort.Results. The prevalence of hypermobility was 13% in the CARRIAGE family and 5% in the GOGO cohort. In the CARRIAGE family, hypermobility was associated with a significantly reduced prevalence of hand (especially proximal interphalangeal joint) and knee OA and lower mean serum COMP levels, both in the total cohort and in non-hand-OA subgroups. These results were further validated in the GOGO subsets without radiographic OA, in which hypermobility was also associated with a significantly reduced mean serum COMP level (P < 0.0001 adjusted for age). Serum RA levels did not differ in relation to hypermobility in either cohort.Conclusion. The present results indicate that there is an inverse relationship between hypermobility and hand and knee OA, and that hypermobility is associated with lower serum COMP levels. Genetic variations of the COMP gene may account for some subgroups of benign joint hypermobility.