Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women
Relationship between brachial arterial endothelial function and lumbar spine bone mineral density in postmenopausal women
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DOI：
10.1253/circj.71.1555
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发表时间：
2007-10-01
影响因子：
3.3
通讯作者：
Kurabayashi, Masahiko
中科院分区：
文献类型：
--
作者：
Sumino, Hiroyuki;Ichikawa, Shuichi;Kurabayashi, Masahiko
背景骨质疏松和内皮功能障碍与动脉粥样硬化有关。方法和结果85例绝经后妇女，其中腰椎骨密度正常者28例，骨量减少者27例，骨质疏松者30例，测定肱动脉内皮功能。通过超声检查评估反应性充血后肱动脉血流介导的血管舒张（FMD）。采用双能X线骨密度仪测量腰椎（腰椎2 ~ 4椎体）的BMD。骨质疏松组的年龄、绝经年限和FMD显著高于BMD正常组（分别为p < 0.01、p < 0.05和p < 0.05）。骨质疏松组骨密度明显低于骨质疏松组和正常骨密度组（均P < 0.01）。校正年龄和绝经年限后，骨质疏松妇女的FMD显著低于BMD正常妇女（p < 0.05）。单因素线性回归分析显示肱动脉FMD与BMD呈显著正相关（r=0.31，p < 0.01），而与其他临床变量无显著相关性。多因素回归分析显示，FMD与BMD呈显著正相关（p < 0.01），与其他变量无相关性。结论绝经后骨质疏松症患者肱动脉内皮功能受损，提示肱动脉内皮功能与绝经后妇女腰椎骨量有关。
Background Osteoporosis and endothelial dysfunction have been associated with atherosclerosis. The correlation between brachial arterial endothelial function and lumbar spine bone mineral density (BMD) in postmenopausal women will be investigated.Methods and Results The endothelial function in 85 postmenopausal women, including 28 women with normal spinal BMD, 27 women with osteopenia, and 30 women with osteoporosis were studied. Brachial arterial flow-mediated vasodilatation (FMD) after reactive hyperemia was assessed by ultrasonography. The BMD at the lumbar spine (lumbar 2 to 4 vertebrae) was measured by dual-energy X-ray absorptiometry. Age, years since menopause, and FMD were significantly greater in the osteoporosis group than in the normal BMD group (p < 0.01, p < 0.05, and p < 0.05, respectively). The BMD was significantly lower in the osteoporosis group than in the osteoporosis or normal BMD group (both p < 0.01). After adjusting for age and years since menopause, women with osteoporosis had significantly lesser FMD than those with normal BMD (p < 0.05). The univariate linear regression analysis revealed that brachial arterial FMD was significantly positively correlated with BMD (r=0.31, p < 0.01), but showed no significant association with other clinical variables. In multivariate regression analysis, the FMD was significantly positively correlated with BMD (p < 0.01), but not with other variables.Conclusions Postmenopausal women with osteoporosis might have impaired brachial arterial endothelial function, suggesting that brachial artery endothelial function might be associated with lumbar spine bone mass in postmenopausal women.