HUNTINGTONS-CHOREA - CHANGES IN NEUROTRANSMITTER RECEPTORS IN BRAIN
HUNTINGTONS-CHOREA - CHANGES IN NEUROTRANSMITTER RECEPTORS IN BRAIN
复制标题
DOI：
10.1056/nejm197606102942402
复制
发表时间：
1976-01-01
影响因子：
158.5
通讯作者：
SNYDER, SH
中科院分区：
文献类型：
--
作者：
ENNA, SJ;BIRD, ED;SNYDER, SH
在来自 16 名亨廷顿舞蹈病患者和 16 名对照者死后大脑的尾状核和额叶大脑皮层中，测量了表观毒蕈碱胆碱能、β-肾上腺素能、GABA 和血清素受体的神经递质受体结合位点。检测样品的 GABA 合成酶、谷氨酸脱羧酶和乙酰胆碱合成酶、胆碱乙酰转移酶。在舞蹈脑的尾状核中，两种酶活性均显着降低，毒蕈碱胆碱能和血清素受体结合显着降低，而大脑皮层中酶活性和受体结合没有变化。相比之下，GABA和β-肾上腺素能受体结合在舞蹈病和控制尾状核或皮质中没有显着差异，这表明尽管纹状体中GABA合成能力丧失，但GABA模拟药物可能缓解亨廷顿舞蹈病的运动障碍。
Neurotransmitter-receptor binding sites for apparent muscarinic cholinergic, .beta.-adrenergic, GABA and serotonin receptors were measured in the caudate nucleus and frontal cerebral cortex from post-mortem brains of 16 patients with Huntington''s chorea and 16 controls. The samples were assayed for the GABA-synthesizing enzyme, glutamic acid decarboxylase, and for the acetylcholine-synthesizing enzyme, choline acetyltransferase. In the caudate nucleus of choreic brain both enzyme activities were markedly lower with significant decreases in muscarinic cholinergic and serotonin receptor binding, whereas enzyme activities and receptor binding were unchanged in the cerebral cortex. By contrast, GABA and .beta.-adrenergic receptor binding were not significantly different in choreic and control caudate nucleus or cortex, suggesting that despite the loss of GABA-synthesizing ability in the corpus striatum, GABA mimetic drugs might alleviate the movement disorders in Hungtington''s chorea.